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- W2084096501 abstract "Pranlukast (PRS) is a leukotriene receptor antagonist for the treatment of bronchial asthma. Pranlukast is formulated as a hemihydrate (HH) form in the drug product. Here, we report three new anhydrate forms of PRS (AH, form I–III). These polymorphs and PRS HH were characterized by PXRD, TG-DTA, simultaneous PXRD-DSC and vapor sorption analysis. In addition, the crystal structures of HH and AH-I were determined by single crystal X-ray structure analysis for the first time. HH transformed to AH-I, AH-II and AH-III as the temperature was increased from 25 °C to 210 °C. At 25 °C, AH-I transformed to HH at above 5%RH. HH and AH-I possessed similar crystal packing patterns and molecular structures." @default.
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- W2084096501 date "2015-03-01" @default.
- W2084096501 modified "2023-09-27" @default.
- W2084096501 title "Physicochemical and crystal structure analysis of pranlukast pseudo-polymorphs I: Anhydrates and hydrate" @default.
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- W2084096501 doi "https://doi.org/10.1016/j.jpba.2014.12.007" @default.
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