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- W2084105436 abstract "The effects of a number of beta-carboline derivatives on [3H]flunitrazepam binding to the benzodiazepine binding site were investigated. The potency of beta-carbolines at the benzodiazepine binding site appeared to be determined largely by the aromaticity of the molecule. Norharmane-3-carboxylic acid ethyl ester was considerably more potent (IC50 10 nM) than its tetrahydro-beta-carboline analogue (IC50 6 microM). There is essentially no difference in potency between the (+)- and (--)-forms of the tetrahydro-beta-carboline-3-carboxylate analogues." @default.
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- W2084105436 date "1981-12-01" @default.
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- W2084105436 title "Interactions of β-carbolines with the benzodiazepine receptor: Structure-activity relationships" @default.
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- W2084105436 doi "https://doi.org/10.1016/0014-2999(81)90515-x" @default.
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