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• W2084121012 abstract "Excessive exposure to ultra-violet (UV) light, the UV-B component (290–230 nm) in particular, represents the most harmful DNA damage-inducing condition that keratinocytes have to face on a regular basis. UV-B exposure induces survivin expression in keratinocytes in vitro [ [1] Dallaglio K. Palazzo E. Marconi A. Dumas M. Truzzi F. Lotti R. et al. Endogenous survivin modulates survival and proliferation in UVB-treated human keratinocytes. Exp Dermatol. 2009; 18: 464-471 Crossref PubMed Scopus (18) Google Scholar ] and in vivo [ [2] Aziz M.H. Ghotra A.S. Shukla Y. Ahmad N. Ultraviolet-B radiation causes an upregulation of survivin in human keratinocytes and mouse skin. Photochem Photobiol. 2004; 80: 602-608 Crossref PubMed Scopus (27) Google Scholar ]. Survivin (BIRC5) is a member of the “inhibitor of apoptosis (IAP)” protein family that can directly or indirectly inhibit caspases, the proteases that mediate apoptosis. Unlike the other members of the family, survivin is also a chromosomal passenger that ensures proper chromosome segregation during cell mitosis. Survivin is often considered as a marker of malignancy, being virtually undetectable in most normal cells and over-expressed in cancer cells [ [3] Wheatley S.P. McNeish I.A. Survivin: a protein with dual roles in mitosis and apoptosis. Int Rev Cytol. 2005; 247: 35-88 Crossref PubMed Scopus (150) Google Scholar ]. In vitro studies indicate that upon stress, survivin may translocate to the cytoplasm [ [4] Asumen M.G. Ifeacho T.V. Cockerham L. Pfandl C. Wall N.R. Dynamic changes to survivin subcellular localization are initiated by DNA damage. Oncol Targets Ther. 2010; 3: 129-137 PubMed Google Scholar ]. The proposed anti-apoptotic mechanisms allowing survivin to protect cells rely on a cytoplasmic location of the protein where it can either inhibit pro-apoptotic proteins or stabilize anti-apoptotic proteins. However, the implication of survivin in anti-apoptotic responses is highly debated [ [5] Yue Z. Carvalho A. Xu Z. Yuan X. Cardinale S. Ribeiro S. et al. Deconstructing survivin: comprehensive genetic analysis of survivin function by conditional knockout in a vertebrate cell line. J Cell Biol. 2008; 183: 279-296 Crossref PubMed Scopus (79) Google Scholar ]. Nevertheless, there is a consensus that, if survivin does have anti-apoptotic functions, this results from its expression in the cytoplasm or its association to the mitochondria [ [6] Connell C.M. Colnaghi R. Wheatley S.P. Nuclear survivin has reduced stability and is not cytoprotective. J Biol Chem. 2008; 283: 3289-3296 Crossref PubMed Scopus (64) Google Scholar ]. Indeed, preventing survivin translocation from the nucleus to the cytoplasm, while not affecting cell division, renders cells more sensitive to irradiation-induced apoptosis [ [7] Colnaghi R. Connell C.M. Barrett R.M. Wheatley S.P. Separating the anti-apoptotic and mitotic roles of survivin. J Biol Chem. 2006; 281: 33450-33456 Crossref PubMed Scopus (115) Google Scholar ]. However, no publication yet has reported the presence of survivin in the cytoplasm of stressed or damaged cells in vivo in non-pathological conditions and hence the physiological role of cytoplasmic survivin is still unclear. The aim of the present study was to define the mode of survivin expression in mouse skin in response to UV-B exposure and determine whether there is an association between survivin expression and apoptosis." @default.
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• W2084121012 date "2012-09-01" @default.
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• W2084121012 title "UV-B induces cytoplasmic survivin expression in mouse epidermis" @default.
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• W2084121012 doi "https://doi.org/10.1016/j.jdermsci.2012.05.007" @default.
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