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• W2084125198 abstract "Intracerebral (i.c.) inoculation of susceptible strains of mice with Theiler's murine encephalomyelitis virus (TMEV) results in immune-mediated demyelination. We examined the role of interferon (IFN)-γ in this virally induced pathogenesis. Intraperitoneal (i.p.) injection of susceptible mice with an IFN-γ neutralizing monoclonal antibody (mAb), DB-1, resulted in a significantly accelerated onset of disease. The anti-IFN-γ mAb-treated animals showed a strong delayed-type hypersensitivity (DTH) response to the virus similar to that of control mAb-treated animals. Treatment with anti-IFN-γ mAb appeared to decrease TMEV-specific mAb titers in one of the protocols used. Intracerebral injection of the anti-IFN-γ mAb had no significant effect on the clinical course of disease. However, intracerebral administration of recombinant IFN-γ significantly accelerated the onset of TMEV-induced disease, as well as enhanced TMEV-specific T cell proliferation and DTH responses. The enhancing effect of IFN-γ was completely abrogated by simultaneous treatment with anti-IFN-γ mAb. Collectively, our data suggest that the level of IF-γ plays a key role in the TMEV-induced inflammatory respopnse and a perturbation of this balance may result in an alteration in the course of the demyelinating disease." @default.
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• W2084125198 date "1994-12-01" @default.
• W2084125198 modified "2023-09-23" @default.
• W2084125198 title "Alteration in the level of interferon-γ results in acceleration of Theiler's virus-induced demyelinating disease" @default.
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• W2084125198 doi "https://doi.org/10.1016/0165-5728(94)90004-3" @default.
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