FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084130767> ?p ?o ?g. }

• W2084130767 endingPage "e27739" @default.
• W2084130767 startingPage "e27739" @default.
• W2084130767 abstract "Capric acid is a second medium-chain fatty acid, and recent studies have shown that fatty acids are associated with bone density and reduce bone turnover. In this study, we investigated the effects of capric acid on lipopolysaccharide (LPS)-induced osteoclastogenesis in RAW264.7 cells. After treatment with capric acid (1 mM), the number of tartrate resistant acid phosphatase (TRAP)-positive cells decreased significantly. Capric acid reduced LPS-induced TRAP expression, an osteoclast differentiation marker, without inhibiting cell viability. LPS strongly upregulated inducible nitric oxide synthase (iNOS) mRNA levels and nitric oxide (NO) production, whereas capric acid inhibited them. Furthermore, capric acid also inhibited monocyte chemoattractant protein-1 (MCP-1) mRNA expression. Subsequently, we investigated various intracellular signaling proteins, including nuclear factor-κB (NF-κB), c-Jun-N-terminal kinase (JNK), extracellular signal regulated kinase 1/2 (ERK1/2), and signal transducer and activator of transcription 1 (STAT1) and STAT3 associated with osteoclastogenesis. Capric acid had no effects on LPS-induced activation of the NF-κB, JNK, ERK1/2, and STAT1 pathways. However, capric acid inhibited LPS-induced phosphorylation of Ser727 in STAT3. Additionally, stattic (a STAT3 inhibitor) inhibited LPS-induced iNOS and MCP-1 gene expression. In conclusion, we demonstrated that capric acid inhibited LPS-induced osteoclastogenesis by suppressing NO production via the STAT3 pathway. These results suggest that capric acid has important therapeutic implications for treating bone diseases associated with excessive osteoclastogenesis." @default.
• W2084130767 created "2016-06-24" @default.
• W2084130767 creator A5004637165 @default.
• W2084130767 creator A5020674417 @default.
• W2084130767 creator A5021294546 @default.
• W2084130767 creator A5065292282 @default.
• W2084130767 creator A5070919578 @default.
• W2084130767 creator A5085844611 @default.
• W2084130767 creator A5087664139 @default.
• W2084130767 date "2011-11-16" @default.
• W2084130767 modified "2023-10-16" @default.
• W2084130767 title "Capric Acid Inhibits NO Production and STAT3 Activation during LPS-Induced Osteoclastogenesis" @default.
• W2084130767 cites W1591881963 @default.
• W2084130767 cites W1772163056 @default.
• W2084130767 cites W1971178687 @default.
• W2084130767 cites W1976146389 @default.
• W2084130767 cites W1977176665 @default.
• W2084130767 cites W1978315640 @default.
• W2084130767 cites W1979528991 @default.
• W2084130767 cites W2000358254 @default.
• W2084130767 cites W2015009800 @default.
• W2084130767 cites W2022633707 @default.
• W2084130767 cites W2027605449 @default.
• W2084130767 cites W2029275361 @default.
• W2084130767 cites W2033793521 @default.
• W2084130767 cites W2036165258 @default.
• W2084130767 cites W2038466746 @default.
• W2084130767 cites W2040873162 @default.
• W2084130767 cites W2054427567 @default.
• W2084130767 cites W2057792332 @default.
• W2084130767 cites W2067648293 @default.
• W2084130767 cites W2071823872 @default.
• W2084130767 cites W2072510816 @default.
• W2084130767 cites W2072668724 @default.
• W2084130767 cites W2075124803 @default.
• W2084130767 cites W2077256934 @default.
• W2084130767 cites W2077908546 @default.
• W2084130767 cites W2081815828 @default.
• W2084130767 cites W2086715846 @default.
• W2084130767 cites W2090145292 @default.
• W2084130767 cites W2093252878 @default.
• W2084130767 cites W2094996941 @default.
• W2084130767 cites W2101025111 @default.
• W2084130767 cites W2106766464 @default.
• W2084130767 cites W2115153703 @default.
• W2084130767 cites W2116121061 @default.
• W2084130767 cites W2120479101 @default.
• W2084130767 cites W2128587187 @default.
• W2084130767 cites W2130386584 @default.
• W2084130767 cites W2130443006 @default.
• W2084130767 cites W2137853875 @default.
• W2084130767 cites W2148946525 @default.
• W2084130767 cites W2149282006 @default.
• W2084130767 cites W2154510859 @default.
• W2084130767 cites W2157299977 @default.
• W2084130767 cites W2157698752 @default.
• W2084130767 cites W2158727573 @default.
• W2084130767 cites W2164636550 @default.
• W2084130767 cites W2243372138 @default.
• W2084130767 cites W2341179483 @default.
• W2084130767 doi "https://doi.org/10.1371/journal.pone.0027739" @default.
• W2084130767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3218024" @default.
• W2084130767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22110749" @default.
• W2084130767 hasPublicationYear "2011" @default.
• W2084130767 type Work @default.
• W2084130767 sameAs 2084130767 @default.
• W2084130767 citedByCount "32" @default.
• W2084130767 countsByYear W20841307672012 @default.
• W2084130767 countsByYear W20841307672013 @default.
• W2084130767 countsByYear W20841307672014 @default.
• W2084130767 countsByYear W20841307672015 @default.
• W2084130767 countsByYear W20841307672016 @default.
• W2084130767 countsByYear W20841307672017 @default.
• W2084130767 countsByYear W20841307672018 @default.
• W2084130767 countsByYear W20841307672019 @default.
• W2084130767 countsByYear W20841307672020 @default.
• W2084130767 countsByYear W20841307672021 @default.
• W2084130767 countsByYear W20841307672022 @default.
• W2084130767 countsByYear W20841307672023 @default.
• W2084130767 crossrefType "journal-article" @default.
• W2084130767 hasAuthorship W2084130767A5004637165 @default.
• W2084130767 hasAuthorship W2084130767A5020674417 @default.
• W2084130767 hasAuthorship W2084130767A5021294546 @default.
• W2084130767 hasAuthorship W2084130767A5065292282 @default.
• W2084130767 hasAuthorship W2084130767A5070919578 @default.
• W2084130767 hasAuthorship W2084130767A5085844611 @default.
• W2084130767 hasAuthorship W2084130767A5087664139 @default.
• W2084130767 hasBestOaLocation W20841307671 @default.
• W2084130767 hasConcept C126322002 @default.
• W2084130767 hasConcept C134018914 @default.
• W2084130767 hasConcept C171958077 @default.
• W2084130767 hasConcept C178790620 @default.
• W2084130767 hasConcept C185592680 @default.
• W2084130767 hasConcept C2777003663 @default.
• W2084130767 hasConcept C2778754761 @default.
• W2084130767 hasConcept C2778923194 @default.
• W2084130767 hasConcept C2781003072 @default.
• W2084130767 hasConcept C2909411929 @default.

• next