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- W2084133074 abstract "In situ hybridization of hepatitis B virus DNA by means of biotinylated probes is a rapid specific histochemical method but it is not very sensitive in formalin-fixed, paraffin-embedded material. The specificity and sensitivity of a new method using a digitonin solution and hydrolytic bath before cytohybridization in 19 formalin-fixed, paraffin-embedded liver biopsies was evaluated and a noticeable increase in staining intensivity observed. Digitonin and hydrochloric acid at low concentration increase the permeability and the diffusion of the bio-probe, improving significantly the sensitivity of reaction. Hepatocytes containing few copies of HBV-DNA were revealed by this method and microscopic visualization of specimens with numerous viral episomes was considerably improved. Therefore cytohybridization can be a specific and sensitive method, even for formalin-fixed, paraffin-embedded material, revealing active HBV replication even in HBcAg negative hepatocytes." @default.
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- W2084133074 date "2008-12-10" @default.
- W2084133074 modified "2023-09-27" @default.
- W2084133074 title "HBV-DNA by in situ hybridization. A method to improve sensitivity on formalin-fixed, paraffinembedded liver biopsies" @default.
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- W2084133074 doi "https://doi.org/10.1111/j.1600-0676.1989.tb00424.x" @default.
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