Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084174815> ?p ?o ?g. }
- W2084174815 endingPage "646" @default.
- W2084174815 startingPage "635" @default.
- W2084174815 abstract "Objective Evaluate the effect of sex and butyrylcholinesterase (BuChE) genotype on the incidence of Alzheimer's disease (AD), cognitive and functional decline, brain volume changes, and response to rivastigmine treatment in individuals with mild cognitive impairment (MCI). Methods This retrospective exploratory analysis from a 3–4 year, randomized, placebo-controlled study of rivastigmine in MCI patients included participants who consented to pharmacogenetic testing. Results Of a total of 1018 patients, 490 [253 (52%) female] were successfully genotyped for BuChE. In patients receiving placebo, the BuChE wt/wt genotype was associated with a statistically significant higher incidence of progression to AD and functional decline in women, compared with men with the BuChE wt/wt genotype. In patients with a BuChE-K allele receiving placebo, incidence of progression to AD and rate of functional decline were not significantly different by sex; however, cognitive decline was significantly faster in men. Statistically significant benefits of rivastigmine treatment on incident AD, functional decline, ventricular volume expansion, whole-brain atrophy, and white matter loss were evident in female BuChE wt/wt. Conclusion Sex and BuChE genotype seem to differentially influence the type of decline in MCI patients, with more rapid progression of cognitive decline in male BuChE-K, and more incident AD and functional decline in female BuChE wt/wt. Cognitive decline in male BuChE-K and functional decline and incident AD in female BuChE wt/wt were significantly attenuated by rivastigmine. Rivastigmine treatment also significantly reduced ventricular expansion, whole-brain atrophy rate, and white matter loss in female BuChE wt/wt, suggesting a possible disease-modifying effect." @default.
- W2084174815 created "2016-06-24" @default.
- W2084174815 creator A5047432836 @default.
- W2084174815 creator A5062039064 @default.
- W2084174815 creator A5062259358 @default.
- W2084174815 creator A5079862221 @default.
- W2084174815 creator A5089411086 @default.
- W2084174815 date "2009-08-01" @default.
- W2084174815 modified "2023-09-30" @default.
- W2084174815 title "Progression from mild cognitive impairment to Alzheimer's disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment" @default.
- W2084174815 cites W163864813 @default.
- W2084174815 cites W1964634864 @default.
- W2084174815 cites W1971048984 @default.
- W2084174815 cites W1971606075 @default.
- W2084174815 cites W1977498406 @default.
- W2084174815 cites W1996748700 @default.
- W2084174815 cites W1996776294 @default.
- W2084174815 cites W1996787470 @default.
- W2084174815 cites W2003590529 @default.
- W2084174815 cites W2005259934 @default.
- W2084174815 cites W2009739635 @default.
- W2084174815 cites W2019147684 @default.
- W2084174815 cites W2024114576 @default.
- W2084174815 cites W2027188977 @default.
- W2084174815 cites W2027971714 @default.
- W2084174815 cites W2028055419 @default.
- W2084174815 cites W2036903387 @default.
- W2084174815 cites W2039595489 @default.
- W2084174815 cites W2042778267 @default.
- W2084174815 cites W2047791499 @default.
- W2084174815 cites W2050668497 @default.
- W2084174815 cites W2055345379 @default.
- W2084174815 cites W2067137499 @default.
- W2084174815 cites W2070495673 @default.
- W2084174815 cites W2070566742 @default.
- W2084174815 cites W2076676029 @default.
- W2084174815 cites W2092698466 @default.
- W2084174815 cites W2109883415 @default.
- W2084174815 cites W2111425471 @default.
- W2084174815 cites W2120772818 @default.
- W2084174815 cites W2126370082 @default.
- W2084174815 cites W2130401688 @default.
- W2084174815 cites W2130582889 @default.
- W2084174815 cites W2130920183 @default.
- W2084174815 cites W2133981072 @default.
- W2084174815 cites W2135336998 @default.
- W2084174815 cites W2149463687 @default.
- W2084174815 cites W2159866533 @default.
- W2084174815 cites W2164145796 @default.
- W2084174815 cites W2171539930 @default.
- W2084174815 cites W3987637 @default.
- W2084174815 doi "https://doi.org/10.1097/fpc.0b013e32832f8c17" @default.
- W2084174815 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4114757" @default.
- W2084174815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19617863" @default.
- W2084174815 hasPublicationYear "2009" @default.
- W2084174815 type Work @default.
- W2084174815 sameAs 2084174815 @default.
- W2084174815 citedByCount "49" @default.
- W2084174815 countsByYear W20841748152012 @default.
- W2084174815 countsByYear W20841748152013 @default.
- W2084174815 countsByYear W20841748152014 @default.
- W2084174815 countsByYear W20841748152015 @default.
- W2084174815 countsByYear W20841748152016 @default.
- W2084174815 countsByYear W20841748152017 @default.
- W2084174815 countsByYear W20841748152018 @default.
- W2084174815 countsByYear W20841748152019 @default.
- W2084174815 countsByYear W20841748152020 @default.
- W2084174815 countsByYear W20841748152021 @default.
- W2084174815 countsByYear W20841748152022 @default.
- W2084174815 countsByYear W20841748152023 @default.
- W2084174815 crossrefType "journal-article" @default.
- W2084174815 hasAuthorship W2084174815A5047432836 @default.
- W2084174815 hasAuthorship W2084174815A5062039064 @default.
- W2084174815 hasAuthorship W2084174815A5062259358 @default.
- W2084174815 hasAuthorship W2084174815A5079862221 @default.
- W2084174815 hasAuthorship W2084174815A5089411086 @default.
- W2084174815 hasBestOaLocation W20841748152 @default.
- W2084174815 hasConcept C120665830 @default.
- W2084174815 hasConcept C121332964 @default.
- W2084174815 hasConcept C126322002 @default.
- W2084174815 hasConcept C142724271 @default.
- W2084174815 hasConcept C15744967 @default.
- W2084174815 hasConcept C181199279 @default.
- W2084174815 hasConcept C204787440 @default.
- W2084174815 hasConcept C27081682 @default.
- W2084174815 hasConcept C2776332859 @default.
- W2084174815 hasConcept C2778816929 @default.
- W2084174815 hasConcept C2779059548 @default.
- W2084174815 hasConcept C2779101902 @default.
- W2084174815 hasConcept C2779134260 @default.
- W2084174815 hasConcept C2779483572 @default.
- W2084174815 hasConcept C2780904820 @default.
- W2084174815 hasConcept C2781172350 @default.
- W2084174815 hasConcept C2984863031 @default.
- W2084174815 hasConcept C55493867 @default.
- W2084174815 hasConcept C61511704 @default.
- W2084174815 hasConcept C71924100 @default.
- W2084174815 hasConcept C86803240 @default.