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- W2084177191 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILIn order to help develop more effective treatment for pancreatic cancer, we developed a multicolor imageable orthotopic mouse model for individual human pancreatic-cancer patients. Pancreatic cancer patient tumor specimens were initially established in SCID-NOD mice. The tumors were then passaged orthotopically into transgenic nude mice expressing GFP in almost every tissue. Both the primary tumors and resultant metastasis acquired GFP stroma and could be imaged by GFP fluorescence. GFP stroma included cancer-associated fibroblasts (CAFs). Further passage to nude mice expressing RFP in almost all tissues resulted in tumors and metastasis acquiring RFP stroma in addition to their GFP stroma, including CAFs. Further passage to transgenic nude mice expressing CFP in almost all tissues resulted in tumors and metastasis acquiring CFP stroma in addition to RFP and GFP stroma including CAFs. The model can be used to image primary and metastatic progression of patient pancreatic tumors, study acquisition of stroma and to test both standard and novel cancer- and stroma-targeting agents. The imageable tumor-graft model should prove valuable for treatment evaluation of individual cancer patients, as well as for evaluation of experimental therapeutics targets in the tumor or the tumor microenvironment such as cancer-associated fibroblasts (CAFs).Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2681. doi:1538-7445.AM2012-2681" @default.
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- W2084177191 date "2012-04-15" @default.
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- W2084177191 title "Abstract 2681: Multicolor imageable orthotopic tumorgraft models of human patient pancreatic cancer" @default.
- W2084177191 doi "https://doi.org/10.1158/1538-7445.am2012-2681" @default.
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