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- W2084178241 abstract "Le développement et la réactivité de la circulation fœtoplacentaire apparaissent comme des phénomènes extrêmement coordonnés, soumis à une chronologie précise, et régulés par de nombreux facteurs angiogéniques et vasoactifs. Lˈendothélium des vaisseaux villositaires par sa capacité à libérer des substances vasodilatatrices jouerait un rôle crucial dans la baisse progressive de la résistance vasculaire placentaire qui permet jusquˈau terme de la grossesse de répondre aux besoins croissants du fœtus. Dans lˈendothélium comme dans la musculature lisse des vaisseaux placentaires, le contrôle de la production et les mécanismes dˈaction des signaux modulateurs du tonus placentaire : endothéline-1, monoxyde dˈazote, prostanoïdes…ainsi que leur dépendance vis-à-vis de lˈoxygène sont loin dˈêtre entièrement élucidés. Lˈétude de leurs interactions pourrait contribuer à mieux évaluer lˈimportance relative de chacun dˈeux dans les équilibres particuliers qui sˈétablissent à différents stades de la grossesse normale ainsi que lors de situations pathologiques (pré-éclampsie, retard de croissance intra-utérin…) quand le flux placentaire et le développement fœtal risquent dˈêtre compromis. The development and the reactivity of fetoplacental circulation appear to be extremely well coordinated phenomena which follow a precise chronology and are regulated by numerous angiogenic and vasoactive factors. The endothelium of the villous vessels, due to its capacity to release vasodilatating substances, would appear to play a crucial role in the gradual decrease in the vascular resistance of the placenta, thereby enabling it to meet the growing needs of the fetus right up until the end of pregnancy. In the endothelium, as in the smooth muscle of the placental vessels, control of production and mechanisms of action of the signal modulators of placental tone - endothelin 1, nitric oxide, prostanoids, etc. – as well as their dependence on oxygen, are far from being entirely elucidated. The study of their interactions could contribute to better evaluating the relative importance of each of them in the particular balances which are established at different stages of normal pregnancy, as well as during pathological situations (pre-eclampsia, intrauterine growth retardation, etc.) when placental blood flow and fetal development are at risk of being compromised." @default.
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- W2084178241 date "2001-07-01" @default.
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- W2084178241 title "Régulation de la circulation fœtale placentaire" @default.
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- W2084178241 doi "https://doi.org/10.1016/s1297-9589(01)00177-1" @default.
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