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• W2084202273 endingPage "1157" @default.
• W2084202273 startingPage "1147" @default.
• W2084202273 abstract "Recently, we identified CyPBP37 of Neurospora crassa as a binding partner of cyclophilin41. CyPBP37 function had not yet been described, although orthologs in other organisms have been implicated in the biosynthesis of the thiazole moiety of thiamine (vitamin B1) and/or stress-related pathways. Here, CyPBP37 is characterized as an abundant cytosolic protein with a functional NAD-binding site. Saccharomyces cerevisiae mutants lacking Thi4p (the CyPBP37 ortholog) are auxotrophic for vitamin B1 (thiamine) but can grow in the presence of the thiazole moiety of thiamine, suggesting a role for Thi4p in the biosynthesis of thiazole. N. crassa CyPBP37 is able to functionally replace Thi4p in yeast thiazole synthesis. Cellular fractionation studies revealed that Thi4p is a cytosolic protein in S. cerevisiae, like its ortholog CyPBP37 in N. crassa. This implies that thiamine synthesis takes place in the cytosol of both organisms and not in the mitochondria, as suggested. The expression of CyPBP37 and Thi4p is repressed by thiamine but not by thiazole in the growth medium. In addition to its function in thiazole synthesis, CyPBP37 is a stress-inducible protein. N. crassa cyclophilin41 can chaperone the folding of CyPBP37, its own binding partner." @default.
• W2084202273 created "2016-06-24" @default.
• W2084202273 creator A5059730328 @default.
• W2084202273 creator A5082809993 @default.
• W2084202273 date "2004-12-01" @default.
• W2084202273 modified "2023-10-18" @default.
• W2084202273 title "Neurospora crassa CyPBP37: A Cytosolic Stress Protein that is able to Replace Yeast Thi4p Function in the Synthesis of Vitamin B1" @default.
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• W2084202273 doi "https://doi.org/10.1016/j.jmb.2004.09.097" @default.
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