Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084215755> ?p ?o ?g. }
- W2084215755 endingPage "215" @default.
- W2084215755 startingPage "203" @default.
- W2084215755 abstract "While estrogen receptor (ER)-targeted therapeutics have clearly been a success in the treatment of breast cancer, the orphan estrogen-related receptors (ERRs) represent novel targets for future development. The ERRs, comprising ERRalpha, ERRbeta and ERRgamma, bind and regulate transcription via estrogen response elements (EREs) and extended ERE half-sites termed ERR response elements (ERREs), but do not bind endogenous estrogens. The emerging role of ERRalpha and ERRgamma in modulating estrogen responsiveness, substituting for ER activities, and serving as prognosticators in breast and other cancers is providing an impetus for the identification of compounds which target these proteins. Moreover, ERRalpha plays a role in energy homeostasis and will likely be targeted for the treatment of metabolic disorders. Multiple classes of synthetic ligands have already been identified. The phytoestrogens genistein, daidzein, biochanin A and 6,3'4'-tryhydroxyflavone have been reported as ERRalpha agonists. The phenolic acyl hydrazones GSK4716 and GSK9089 act as selective agonists of ERRbeta and ERRgamma. The organochlorine pesticides toxaphene and chlordane, and the synthetic compound XCT790 antagonize ERRalpha. The synthetic estrogen diethylstilbestrol antagonizes all three ERRs. The selective estrogen receptor modulators 4-hydroxytamoxifen and 4-hydroxytoremifene antagonize ERRgamma. The rational development of synthetic ligands for the ERRs may soon provide new agents to supplement the repertoire of antihormonal therapies to combat breast cancer. Moreover, expression of ERRs in other cancers and metabolic disorders may provide a targeted treatment strategy for these patients as well." @default.
- W2084215755 created "2016-06-24" @default.
- W2084215755 creator A5049919852 @default.
- W2084215755 creator A5053893712 @default.
- W2084215755 date "2006-02-01" @default.
- W2084215755 modified "2023-09-25" @default.
- W2084215755 title "Estrogen-Related Receptors as Emerging Targets in Cancer and Metabolic Disorders" @default.
- W2084215755 cites W1504308000 @default.
- W2084215755 cites W1510569968 @default.
- W2084215755 cites W1592442641 @default.
- W2084215755 cites W1592463243 @default.
- W2084215755 cites W1599762863 @default.
- W2084215755 cites W1605945811 @default.
- W2084215755 cites W1720495713 @default.
- W2084215755 cites W1781542121 @default.
- W2084215755 cites W1843361147 @default.
- W2084215755 cites W1850971480 @default.
- W2084215755 cites W1965989272 @default.
- W2084215755 cites W1965989762 @default.
- W2084215755 cites W1969188404 @default.
- W2084215755 cites W1969708640 @default.
- W2084215755 cites W1975478809 @default.
- W2084215755 cites W1985897362 @default.
- W2084215755 cites W1990579890 @default.
- W2084215755 cites W1991108075 @default.
- W2084215755 cites W2000065704 @default.
- W2084215755 cites W2002246903 @default.
- W2084215755 cites W2007835667 @default.
- W2084215755 cites W2013076477 @default.
- W2084215755 cites W2015985353 @default.
- W2084215755 cites W2017002112 @default.
- W2084215755 cites W2019989477 @default.
- W2084215755 cites W2026298200 @default.
- W2084215755 cites W2026948301 @default.
- W2084215755 cites W2031039400 @default.
- W2084215755 cites W2032136115 @default.
- W2084215755 cites W2032356402 @default.
- W2084215755 cites W2035416275 @default.
- W2084215755 cites W2036134589 @default.
- W2084215755 cites W2040638528 @default.
- W2084215755 cites W2051395127 @default.
- W2084215755 cites W2052404791 @default.
- W2084215755 cites W2055570003 @default.
- W2084215755 cites W2056385716 @default.
- W2084215755 cites W2057207799 @default.
- W2084215755 cites W2059823851 @default.
- W2084215755 cites W2066260773 @default.
- W2084215755 cites W2071494447 @default.
- W2084215755 cites W2072354324 @default.
- W2084215755 cites W2072410686 @default.
- W2084215755 cites W2085615104 @default.
- W2084215755 cites W2087393295 @default.
- W2084215755 cites W2090144285 @default.
- W2084215755 cites W2093535482 @default.
- W2084215755 cites W2093718545 @default.
- W2084215755 cites W2093930291 @default.
- W2084215755 cites W2094633969 @default.
- W2084215755 cites W2098290877 @default.
- W2084215755 cites W2105933366 @default.
- W2084215755 cites W2111650618 @default.
- W2084215755 cites W2112980664 @default.
- W2084215755 cites W2114712908 @default.
- W2084215755 cites W2117464070 @default.
- W2084215755 cites W2119554992 @default.
- W2084215755 cites W2121281422 @default.
- W2084215755 cites W2122265031 @default.
- W2084215755 cites W2127436763 @default.
- W2084215755 cites W2128284013 @default.
- W2084215755 cites W2130235602 @default.
- W2084215755 cites W2131492087 @default.
- W2084215755 cites W2137920359 @default.
- W2084215755 cites W2146369010 @default.
- W2084215755 cites W2148992247 @default.
- W2084215755 cites W2150479378 @default.
- W2084215755 cites W2150695819 @default.
- W2084215755 cites W2150869416 @default.
- W2084215755 cites W2158288874 @default.
- W2084215755 cites W2166404930 @default.
- W2084215755 cites W2168878790 @default.
- W2084215755 cites W2172200901 @default.
- W2084215755 cites W2339816043 @default.
- W2084215755 doi "https://doi.org/10.2174/1568026610606030203" @default.
- W2084215755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16515477" @default.
- W2084215755 hasPublicationYear "2006" @default.
- W2084215755 type Work @default.
- W2084215755 sameAs 2084215755 @default.
- W2084215755 citedByCount "128" @default.
- W2084215755 countsByYear W20842157552012 @default.
- W2084215755 countsByYear W20842157552013 @default.
- W2084215755 countsByYear W20842157552014 @default.
- W2084215755 countsByYear W20842157552015 @default.
- W2084215755 countsByYear W20842157552016 @default.
- W2084215755 countsByYear W20842157552017 @default.
- W2084215755 countsByYear W20842157552018 @default.
- W2084215755 countsByYear W20842157552019 @default.
- W2084215755 countsByYear W20842157552020 @default.
- W2084215755 countsByYear W20842157552021 @default.
- W2084215755 countsByYear W20842157552022 @default.