Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084224839> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2084224839 endingPage "310" @default.
- W2084224839 startingPage "306" @default.
- W2084224839 abstract "Coniine, an alkaloid from Conium maculatum (poison hemlock), has been shown to be teratogenic in livestock. The major ter-atogenic outcome is arthrogryposis, presumably due to nicotinic receptor blockade. However, coniine has failed to produce arthrogryposis in rats or mice and is only weakly teratogenic in rabbits. The purpose of this study was to evaluate and compare the effects of coniine and nicotine in the developing chick. Concentrations of coniine and nicotine sulfate were 0.015%, 0.03%, 0.075%, 0.15%, 0.75%, 1.5%, 3%, and 6% and 1%, 5%, and 10%, respectively. Both compounds caused deformations and lethality in a dose-dependent manner. All concentrations of nicotine sulfate caused some lethality but a no effect level for coniine lethality was 0.75%. The deformations caused by both coniine and nicotine sulfate were excessive flexion or extension of one or more toes. No histopathological alterations or differences in bone formation were seen in the limbs or toes of any chicks from any group; however, extensive cranial hemorrhage occurred in all nicotine sulfate-treated chicks. There was a statistically significant (P ≤ 0.01) decrease in movement in coniine and nicotine sulfate treated chicks as determined by ultrasound. Control chicks were in motion an average of 33.67% of the time, while coniine-treated chicks were only moving 8.95% of a 5-min interval, and no movement was observed for nicotine sulfate treated chicks. In summary, the chick embryo provides a reliable and simple experimental animal model of coniine-induced arthrogryposis. Data from this model support a mechanism involving nicotinic receptor blockade with subsequent decreased fetal movement. © 1994 Wiley-Liss, Inc." @default.
- W2084224839 created "2016-06-24" @default.
- W2084224839 creator A5005752144 @default.
- W2084224839 creator A5014860495 @default.
- W2084224839 creator A5028590065 @default.
- W2084224839 creator A5046315088 @default.
- W2084224839 date "1994-04-01" @default.
- W2084224839 modified "2023-10-16" @default.
- W2084224839 title "Effect of coniine on the developing chick embryo" @default.
- W2084224839 cites W1975991432 @default.
- W2084224839 cites W2017806349 @default.
- W2084224839 cites W2034497612 @default.
- W2084224839 cites W2140034535 @default.
- W2084224839 cites W2157942250 @default.
- W2084224839 doi "https://doi.org/10.1002/tera.1420490410" @default.
- W2084224839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8073369" @default.
- W2084224839 hasPublicationYear "1994" @default.
- W2084224839 type Work @default.
- W2084224839 sameAs 2084224839 @default.
- W2084224839 citedByCount "14" @default.
- W2084224839 countsByYear W20842248392012 @default.
- W2084224839 countsByYear W20842248392013 @default.
- W2084224839 countsByYear W20842248392015 @default.
- W2084224839 countsByYear W20842248392016 @default.
- W2084224839 countsByYear W20842248392019 @default.
- W2084224839 countsByYear W20842248392021 @default.
- W2084224839 crossrefType "journal-article" @default.
- W2084224839 hasAuthorship W2084224839A5005752144 @default.
- W2084224839 hasAuthorship W2084224839A5014860495 @default.
- W2084224839 hasAuthorship W2084224839A5028590065 @default.
- W2084224839 hasAuthorship W2084224839A5046315088 @default.
- W2084224839 hasConcept C126322002 @default.
- W2084224839 hasConcept C134018914 @default.
- W2084224839 hasConcept C172680121 @default.
- W2084224839 hasConcept C185592680 @default.
- W2084224839 hasConcept C2777667214 @default.
- W2084224839 hasConcept C2779234561 @default.
- W2084224839 hasConcept C2779547902 @default.
- W2084224839 hasConcept C54355233 @default.
- W2084224839 hasConcept C65290608 @default.
- W2084224839 hasConcept C71240020 @default.
- W2084224839 hasConcept C71924100 @default.
- W2084224839 hasConcept C86803240 @default.
- W2084224839 hasConcept C98274493 @default.
- W2084224839 hasConceptScore W2084224839C126322002 @default.
- W2084224839 hasConceptScore W2084224839C134018914 @default.
- W2084224839 hasConceptScore W2084224839C172680121 @default.
- W2084224839 hasConceptScore W2084224839C185592680 @default.
- W2084224839 hasConceptScore W2084224839C2777667214 @default.
- W2084224839 hasConceptScore W2084224839C2779234561 @default.
- W2084224839 hasConceptScore W2084224839C2779547902 @default.
- W2084224839 hasConceptScore W2084224839C54355233 @default.
- W2084224839 hasConceptScore W2084224839C65290608 @default.
- W2084224839 hasConceptScore W2084224839C71240020 @default.
- W2084224839 hasConceptScore W2084224839C71924100 @default.
- W2084224839 hasConceptScore W2084224839C86803240 @default.
- W2084224839 hasConceptScore W2084224839C98274493 @default.
- W2084224839 hasIssue "4" @default.
- W2084224839 hasLocation W20842248391 @default.
- W2084224839 hasLocation W20842248392 @default.
- W2084224839 hasOpenAccess W2084224839 @default.
- W2084224839 hasPrimaryLocation W20842248391 @default.
- W2084224839 hasRelatedWork W2062430536 @default.
- W2084224839 hasRelatedWork W2105068995 @default.
- W2084224839 hasRelatedWork W2133617154 @default.
- W2084224839 hasRelatedWork W2150404404 @default.
- W2084224839 hasRelatedWork W2413286353 @default.
- W2084224839 hasRelatedWork W2417310453 @default.
- W2084224839 hasRelatedWork W2417689426 @default.
- W2084224839 hasRelatedWork W2419668790 @default.
- W2084224839 hasRelatedWork W2748952813 @default.
- W2084224839 hasRelatedWork W614425779 @default.
- W2084224839 hasVolume "49" @default.
- W2084224839 isParatext "false" @default.
- W2084224839 isRetracted "false" @default.
- W2084224839 magId "2084224839" @default.
- W2084224839 workType "article" @default.