FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084227977> ?p ?o ?g. }

• W2084227977 endingPage "33" @default.
• W2084227977 startingPage "25" @default.
• W2084227977 abstract "To study the influence of dopaminergic activity on the expression of dopamine D 2 receptors and glutamic acid decarboxylase in substantia nigra, mice were treated daily for several days with an irreversibly acting dopamine D 1 and dopamine D 2 receptor antagonist N -ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) or with a selective irreversible D 2 dopamine receptor antagonist fluphenazine- N -mustard. Mice were killed 24 h after the last injection. Dopamine D 1 and dopamine D 2 receptors were determined by receptor autoradiography, and dopamine D 1 and dopamine D 2 receptor mRNA and glutamic acid decarboxylase mRNA were determined by in situ hybridization histochemistry. The results showed that treatment with EEDQ, which blocked 80% to 85% of the dopamine D 2 and dopamine D 1 receptors in substantia nigra, increased the levels of dopamine D 2 receptor mRNA in substantia nigra by about 27%. Treatment with fluphenazine- N -mustard, which blocked about 85% of the dopamine D 2 receptors in substantia nigra but had no significant effect on dopamine D 1 receptor, increased the levels of dopamine D 2 receptor mRNA by about 34%. There were no detectable levels of dopamine D 1 receptor mRNA in substantia nigra either in control animals or in animals treated with the dopamine receptor antagonists. Glutamic acid decarboxylase mRNA was expressed in several regions of the mid-brain but only that expressed in substantia nigra was altered by treatment with dopamine receptor antagonists. The levels of glutamic acid decarboxylase mRNA in substantia nigra increased by 83% following EEDQ treatment, and by 50% following treatment with fluphenazine- N -mustard. These results suggested that dopamine receptors, particularly dopamine D 2 receptors, play an important role in regulating the expression of both dopamine D 2 receptor mRNA and glutamic acid decarboxylase mRNA in substantia nigra." @default.
• W2084227977 created "2016-06-24" @default.
• W2084227977 creator A5018377073 @default.
• W2084227977 creator A5041287759 @default.
• W2084227977 date "1994-09-01" @default.
• W2084227977 modified "2023-10-16" @default.
• W2084227977 title "Dopamine receptor blockade increases dopamine D2 receptor and glutamic acid decarboxylase mRNAs in mouse substantia nigra" @default.
• W2084227977 cites W1964212502 @default.
• W2084227977 cites W1965835054 @default.
• W2084227977 cites W1978850926 @default.
• W2084227977 cites W1979547579 @default.
• W2084227977 cites W1985578899 @default.
• W2084227977 cites W1985888173 @default.
• W2084227977 cites W1987911844 @default.
• W2084227977 cites W1989015059 @default.
• W2084227977 cites W1991005398 @default.
• W2084227977 cites W1991603311 @default.
• W2084227977 cites W1992903018 @default.
• W2084227977 cites W1999961963 @default.
• W2084227977 cites W2002227992 @default.
• W2084227977 cites W2003119451 @default.
• W2084227977 cites W2004156074 @default.
• W2084227977 cites W2005255727 @default.
• W2084227977 cites W2013526287 @default.
• W2084227977 cites W2015617420 @default.
• W2084227977 cites W2015723254 @default.
• W2084227977 cites W2017245582 @default.
• W2084227977 cites W2018212332 @default.
• W2084227977 cites W2021893363 @default.
• W2084227977 cites W2023392537 @default.
• W2084227977 cites W2023607823 @default.
• W2084227977 cites W2025564011 @default.
• W2084227977 cites W2028247815 @default.
• W2084227977 cites W2041662674 @default.
• W2084227977 cites W2044556326 @default.
• W2084227977 cites W2045094057 @default.
• W2084227977 cites W2046302119 @default.
• W2084227977 cites W2051876512 @default.
• W2084227977 cites W2052871579 @default.
• W2084227977 cites W2053031834 @default.
• W2084227977 cites W2054499859 @default.
• W2084227977 cites W2060588252 @default.
• W2084227977 cites W2067787254 @default.
• W2084227977 cites W2071863377 @default.
• W2084227977 cites W2073441634 @default.
• W2084227977 cites W2073947145 @default.
• W2084227977 cites W2077941720 @default.
• W2084227977 cites W2078720581 @default.
• W2084227977 cites W2079545124 @default.
• W2084227977 cites W2080914638 @default.
• W2084227977 cites W2081277244 @default.
• W2084227977 cites W2088695957 @default.
• W2084227977 cites W2096441504 @default.
• W2084227977 cites W2155532496 @default.
• W2084227977 cites W2416672555 @default.
• W2084227977 cites W2434724910 @default.
• W2084227977 doi "https://doi.org/10.1016/0922-4106(94)90022-1" @default.
• W2084227977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7828655" @default.
• W2084227977 hasPublicationYear "1994" @default.
• W2084227977 type Work @default.
• W2084227977 sameAs 2084227977 @default.
• W2084227977 citedByCount "10" @default.
• W2084227977 countsByYear W20842279772013 @default.
• W2084227977 crossrefType "journal-article" @default.
• W2084227977 hasAuthorship W2084227977A5018377073 @default.
• W2084227977 hasAuthorship W2084227977A5041287759 @default.
• W2084227977 hasConcept C120069818 @default.
• W2084227977 hasConcept C120750228 @default.
• W2084227977 hasConcept C126322002 @default.
• W2084227977 hasConcept C134018914 @default.
• W2084227977 hasConcept C137183658 @default.
• W2084227977 hasConcept C181199279 @default.
• W2084227977 hasConcept C185592680 @default.
• W2084227977 hasConcept C199596767 @default.
• W2084227977 hasConcept C2780938664 @default.
• W2084227977 hasConcept C44208683 @default.
• W2084227977 hasConcept C513476851 @default.
• W2084227977 hasConcept C55493867 @default.
• W2084227977 hasConcept C71924100 @default.
• W2084227977 hasConcept C86803240 @default.
• W2084227977 hasConcept C9497952 @default.
• W2084227977 hasConcept C98274493 @default.
• W2084227977 hasConceptScore W2084227977C120069818 @default.
• W2084227977 hasConceptScore W2084227977C120750228 @default.
• W2084227977 hasConceptScore W2084227977C126322002 @default.
• W2084227977 hasConceptScore W2084227977C134018914 @default.
• W2084227977 hasConceptScore W2084227977C137183658 @default.
• W2084227977 hasConceptScore W2084227977C181199279 @default.
• W2084227977 hasConceptScore W2084227977C185592680 @default.
• W2084227977 hasConceptScore W2084227977C199596767 @default.
• W2084227977 hasConceptScore W2084227977C2780938664 @default.
• W2084227977 hasConceptScore W2084227977C44208683 @default.
• W2084227977 hasConceptScore W2084227977C513476851 @default.
• W2084227977 hasConceptScore W2084227977C55493867 @default.
• W2084227977 hasConceptScore W2084227977C71924100 @default.
• W2084227977 hasConceptScore W2084227977C86803240 @default.
• W2084227977 hasConceptScore W2084227977C9497952 @default.
• W2084227977 hasConceptScore W2084227977C98274493 @default.

• next