FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084232502> ?p ?o ?g. }

• W2084232502 endingPage "183" @default.
• W2084232502 startingPage "183" @default.
• W2084232502 abstract "Many vasoconstrictors (spasmogens) may cause arterial graft spasm; however, there is lack of an overview of the nature of vasoconstriction in grafts. This study was designed to investigate the response of three major arterial grafts currently used for coronary artery bypass grafting to various vasoconstrictor substances. Segments of three arterial grafts (gastroepiploic [GEA], n = 28; internal mammary [IMA], n = 213; inferior epigastric [IEA], n = 24) taken from patients undergoing coronary artery bypass grafting were studied in organ baths under a physiologic pressure. Cumulative concentration-contraction curves were established for the following vasoconstrictor substances: endothelin-1, U46619, prostaglandin F2α, norepinephrine, methoxamine, phenylephrine, 5-hydroxytryptamine, and potassium chloride (K+). In IMA, the highest contraction force was induced by U46619 (5.69 ± 0.48 g), endothelin-1 (4.43 ± 0.4 g), PGF2α (6.29 ± 1.42 g), and K+ (4.58 ± 0.5 g). Internal mammary artery is highly sensitive to endothelin-1 (EC50, −8.13 ± 0.08 log M) and U46619 (EC50, −8.21 ± 0.21 log M) (lower than any other vasoconstrictors, p < 0.001). Next sensitive vasoconstrictors were PGF2α and norepinephrine. 5-Hydroxytryptamine induced significantly higher contraction force in the IMA without endothelium (2.8 ± 0.64 g versus 1.4 ± 0.23 g, p < 0.05). In GEA and IEA, endothelin-1 and U46619 were more potent vasoconstrictors (EC50 for endothelin-1: −8.06 ± 0.02 log M in GEA and −8.22 ± 0.04 in IEA; for U46619: −8.49 ± 0.24 log M in GEA and −8.25 ± 0.09 in IEA) than that for norepinephrine (−6.86 ± 0.11 log M for GEA and −6.59 ± 0.18 log M for IEA, p < 0.0001), although all of them (and K+) evoked a strong contraction. In summary, the present study reveals that there are basically two types of vasoconstrictors that are important spasmogens in arterial grafts. Type I (endothelin, prostaglandins (thromboxane A2 and prostaglandin F2α), and α1-adrenoceptor agonists) are the most potent vasoconstrictors and they strongly contract arterial grafts even when endothelium is intact. Type II vasoconstrictors (such as 5-HT) only induce a weak vasoconstriction when endothelium is intact. However, those vasoconstrictors probably play an important role in the spasm of arterial grafts if endothelium is lost by surgical handling." @default.
• W2084232502 created "2016-06-24" @default.
• W2084232502 creator A5021047804 @default.
• W2084232502 creator A5021902692 @default.
• W2084232502 creator A5035044721 @default.
• W2084232502 creator A5046988442 @default.
• W2084232502 creator A5067311661 @default.
• W2084232502 creator A5071698704 @default.
• W2084232502 date "1995-01-01" @default.
• W2084232502 modified "2023-09-27" @default.
• W2084232502 title "Potassium channel activators in the management of graft spasm" @default.
• W2084232502 doi "https://doi.org/10.1016/1043-6618(95)86992-1" @default.
• W2084232502 hasPublicationYear "1995" @default.
• W2084232502 type Work @default.
• W2084232502 sameAs 2084232502 @default.
• W2084232502 citedByCount "0" @default.
• W2084232502 crossrefType "journal-article" @default.
• W2084232502 hasAuthorship W2084232502A5021047804 @default.
• W2084232502 hasAuthorship W2084232502A5021902692 @default.
• W2084232502 hasAuthorship W2084232502A5035044721 @default.
• W2084232502 hasAuthorship W2084232502A5046988442 @default.
• W2084232502 hasAuthorship W2084232502A5067311661 @default.
• W2084232502 hasAuthorship W2084232502A5071698704 @default.
• W2084232502 hasConcept C126322002 @default.
• W2084232502 hasConcept C144980905 @default.
• W2084232502 hasConcept C163415756 @default.
• W2084232502 hasConcept C164705383 @default.
• W2084232502 hasConcept C170493617 @default.
• W2084232502 hasConcept C2776820930 @default.
• W2084232502 hasConcept C2777952589 @default.
• W2084232502 hasConcept C2778938600 @default.
• W2084232502 hasConcept C2779961880 @default.
• W2084232502 hasConcept C2780745239 @default.
• W2084232502 hasConcept C42219234 @default.
• W2084232502 hasConcept C71924100 @default.
• W2084232502 hasConcept C84393581 @default.
• W2084232502 hasConceptScore W2084232502C126322002 @default.
• W2084232502 hasConceptScore W2084232502C144980905 @default.
• W2084232502 hasConceptScore W2084232502C163415756 @default.
• W2084232502 hasConceptScore W2084232502C164705383 @default.
• W2084232502 hasConceptScore W2084232502C170493617 @default.
• W2084232502 hasConceptScore W2084232502C2776820930 @default.
• W2084232502 hasConceptScore W2084232502C2777952589 @default.
• W2084232502 hasConceptScore W2084232502C2778938600 @default.
• W2084232502 hasConceptScore W2084232502C2779961880 @default.
• W2084232502 hasConceptScore W2084232502C2780745239 @default.
• W2084232502 hasConceptScore W2084232502C42219234 @default.
• W2084232502 hasConceptScore W2084232502C71924100 @default.
• W2084232502 hasConceptScore W2084232502C84393581 @default.
• W2084232502 hasLocation W20842325021 @default.
• W2084232502 hasOpenAccess W2084232502 @default.
• W2084232502 hasPrimaryLocation W20842325021 @default.
• W2084232502 hasRelatedWork W1713638464 @default.
• W2084232502 hasRelatedWork W2001851787 @default.
• W2084232502 hasRelatedWork W2023398288 @default.
• W2084232502 hasRelatedWork W2031250397 @default.
• W2084232502 hasRelatedWork W2071102879 @default.
• W2084232502 hasRelatedWork W2163462889 @default.
• W2084232502 hasRelatedWork W2393278514 @default.
• W2084232502 hasRelatedWork W2414837029 @default.
• W2084232502 hasRelatedWork W3196663550 @default.
• W2084232502 hasRelatedWork W632810138 @default.
• W2084232502 hasVolume "31" @default.
• W2084232502 isParatext "false" @default.
• W2084232502 isRetracted "false" @default.
• W2084232502 magId "2084232502" @default.
• W2084232502 workType "article" @default.