FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084248110> ?p ?o ?g. }

• W2084248110 endingPage "332" @default.
• W2084248110 startingPage "324" @default.
• W2084248110 abstract "Oxysterols, such as 7β-hydroxy-cholesterol (7β-OH) and cholesterol-5β,6β-epoxide (β-epoxide), may have a central role in promoting atherogenesis. This is thought to be predominantly due to their ability to induce apoptosis in cells of the vascular wall and in monocytes/macrophages. Although there has been extensive research regarding the mechanisms through which oxysterols induce apoptosis, much remains to be clarified. Given that experimental evidence has long associated alterations of calcium (Ca2+) homeostasis to apoptotic cell death, the aim of the present study was to determine the influence of intracellular Ca2+ changes on apoptosis induced by 7β-OH and β-epoxide. Ca2+ responses in differentiated U937 cells were assessed by epifluorescence video microscopy, using the ratiometric dye fura-2. Over 15-min exposure of differentiated U937 cells to 30 μM of 7β-OH induced a slow but significant rise in fura-2 ratio. The Ca2+ channel blocker nifedipine and the chelating agent EGTA blocked the increase in cytoplasmic Ca2+. Moreover, dihydropyridine (DHP) binding sites identified with BODIPY-FLX-DHP were blocked following pretreatment with nifedipine, indicating that the influx of Ca2+ occurred through L-type channels. However, following long-term incubation with 7β-OH, elevated levels of cytoplasmic Ca2+ were not maintained and nifedipine did not provide protection against apoptotic cell death. Our results indicate that the increase in Ca2+ may be an initial trigger of 7β-OH–induced apoptosis, but following chronic exposure to the oxysterol, the influence of Ca2+ on apoptotic cell death appears to be less significant. In contrast, Ca2+ did not appear to be involved in β-epoxide–induced apoptosis. © 2009 Wiley Periodicals, Inc. J Biochem Mol Toxicol 23:324–332, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20295" @default.
• W2084248110 created "2016-06-24" @default.
• W2084248110 creator A5015269041 @default.
• W2084248110 creator A5058027348 @default.
• W2084248110 creator A5074266219 @default.
• W2084248110 date "2009-09-01" @default.
• W2084248110 modified "2023-10-17" @default.
• W2084248110 title "The role of calcium in apoptosis induced by 7β-hydroxycholesterol and cholesterol-5β,6β-epoxide" @default.
• W2084248110 cites W1265747563 @default.
• W2084248110 cites W1493322929 @default.
• W2084248110 cites W1522731616 @default.
• W2084248110 cites W1968619647 @default.
• W2084248110 cites W1970189293 @default.
• W2084248110 cites W1986775771 @default.
• W2084248110 cites W1993720376 @default.
• W2084248110 cites W2000819862 @default.
• W2084248110 cites W2003667131 @default.
• W2084248110 cites W2008757142 @default.
• W2084248110 cites W2010835380 @default.
• W2084248110 cites W2011972906 @default.
• W2084248110 cites W2018695514 @default.
• W2084248110 cites W2021262302 @default.
• W2084248110 cites W2023856781 @default.
• W2084248110 cites W2030790708 @default.
• W2084248110 cites W2036764305 @default.
• W2084248110 cites W2039974363 @default.
• W2084248110 cites W2041187778 @default.
• W2084248110 cites W2042252937 @default.
• W2084248110 cites W2056459432 @default.
• W2084248110 cites W2056927666 @default.
• W2084248110 cites W2058383884 @default.
• W2084248110 cites W2071277703 @default.
• W2084248110 cites W2084742082 @default.
• W2084248110 cites W2085780806 @default.
• W2084248110 cites W2092468599 @default.
• W2084248110 cites W2095113625 @default.
• W2084248110 cites W2108917325 @default.
• W2084248110 cites W2113516749 @default.
• W2084248110 cites W2113574245 @default.
• W2084248110 cites W2113937251 @default.
• W2084248110 cites W2115457290 @default.
• W2084248110 cites W2138298723 @default.
• W2084248110 cites W2173877678 @default.
• W2084248110 cites W397376657 @default.
• W2084248110 cites W4255760236 @default.
• W2084248110 doi "https://doi.org/10.1002/jbt.20295" @default.
• W2084248110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19827036" @default.
• W2084248110 hasPublicationYear "2009" @default.
• W2084248110 type Work @default.
• W2084248110 sameAs 2084248110 @default.
• W2084248110 citedByCount "20" @default.
• W2084248110 countsByYear W20842481102012 @default.
• W2084248110 countsByYear W20842481102013 @default.
• W2084248110 countsByYear W20842481102015 @default.
• W2084248110 countsByYear W20842481102017 @default.
• W2084248110 countsByYear W20842481102019 @default.
• W2084248110 countsByYear W20842481102020 @default.
• W2084248110 countsByYear W20842481102021 @default.
• W2084248110 crossrefType "journal-article" @default.
• W2084248110 hasAuthorship W2084248110A5015269041 @default.
• W2084248110 hasAuthorship W2084248110A5058027348 @default.
• W2084248110 hasAuthorship W2084248110A5074266219 @default.
• W2084248110 hasConcept C108634530 @default.
• W2084248110 hasConcept C126322002 @default.
• W2084248110 hasConcept C134018914 @default.
• W2084248110 hasConcept C178790620 @default.
• W2084248110 hasConcept C181080969 @default.
• W2084248110 hasConcept C181199279 @default.
• W2084248110 hasConcept C185592680 @default.
• W2084248110 hasConcept C190283241 @default.
• W2084248110 hasConcept C2777658833 @default.
• W2084248110 hasConcept C2778111914 @default.
• W2084248110 hasConcept C2778163477 @default.
• W2084248110 hasConcept C2778470358 @default.
• W2084248110 hasConcept C2779066535 @default.
• W2084248110 hasConcept C2780356492 @default.
• W2084248110 hasConcept C31573885 @default.
• W2084248110 hasConcept C519063684 @default.
• W2084248110 hasConcept C55493867 @default.
• W2084248110 hasConcept C71924100 @default.
• W2084248110 hasConcept C79879829 @default.
• W2084248110 hasConcept C86803240 @default.
• W2084248110 hasConcept C87975464 @default.
• W2084248110 hasConcept C95444343 @default.
• W2084248110 hasConcept C98539663 @default.
• W2084248110 hasConceptScore W2084248110C108634530 @default.
• W2084248110 hasConceptScore W2084248110C126322002 @default.
• W2084248110 hasConceptScore W2084248110C134018914 @default.
• W2084248110 hasConceptScore W2084248110C178790620 @default.
• W2084248110 hasConceptScore W2084248110C181080969 @default.
• W2084248110 hasConceptScore W2084248110C181199279 @default.
• W2084248110 hasConceptScore W2084248110C185592680 @default.
• W2084248110 hasConceptScore W2084248110C190283241 @default.
• W2084248110 hasConceptScore W2084248110C2777658833 @default.
• W2084248110 hasConceptScore W2084248110C2778111914 @default.
• W2084248110 hasConceptScore W2084248110C2778163477 @default.
• W2084248110 hasConceptScore W2084248110C2778470358 @default.
• W2084248110 hasConceptScore W2084248110C2779066535 @default.

• next