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- W2084249119 startingPage "20140070" @default.
- W2084249119 abstract "We here review the evolution of invasive placentation in primates towards the deep penetration of the endometrium and its arteries in hominoids. The strepsirrhine primates (lemurs and lorises) have non-invasive, epitheliochorial placentation, although this is thought to be derived from a more invasive type. In haplorhine primates, there is differentiation of trophoblast at the blastocyst stage into syncytial and cellular trophoblast. Implantation involves syncytiotrophoblast that first removes the uterine epithelium then consolidates at the basal lamina before continuing into the stroma. In later stages of pregnancy, especially in Old World monkeys and apes, cytotrophoblast plays a greater role in the invasive process. Columns of trophoblast cells advance to the base of the implantation site where they spread out to form a cytotrophoblastic shell. In addition, cytotrophoblasts advance into the lumen of the spiral arteries. They are responsible for remodelling these vessels to form wide, low-resistance conduits. In human and great apes, there is additional invasion of the endometrium and its vessels by trophoblasts originating from the base of the anchoring villi. Deep trophoblast invasion that extends remodelling of the spiral arteries to segments in the inner myometrium evolved in the common ancestor of gorilla, chimp and human." @default.
- W2084249119 created "2016-06-24" @default.
- W2084249119 creator A5043848390 @default.
- W2084249119 creator A5044419724 @default.
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- W2084249119 date "2015-03-05" @default.
- W2084249119 modified "2023-10-16" @default.
- W2084249119 title "The role of invasive trophoblast in implantation and placentation of primates" @default.
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- W2084249119 doi "https://doi.org/10.1098/rstb.2014.0070" @default.
- W2084249119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4305171" @default.
- W2084249119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25602074" @default.
- W2084249119 hasPublicationYear "2015" @default.
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