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- W2084253027 abstract "Many studies have examined pathways controlling effector T cell differentiation, but less is known about the fate of individual CD8+ T cells during infection. Here, we examine the antiviral and antibacterial responses of single CD8+ T cells from the polyclonal repertoire. The progeny of naive clonal CD8+ T cells displayed unique profiles of differentiation based on extrinsic pathogen-induced environmental cues, with some clones demonstrating extreme bias toward a single developmental pathway. Moreover, even within the same animal, a single naive CD8+ T cell exhibited distinct fates that were controlled by tissue-specific events. However, memory CD8+ T cells relied on intrinsic factors to control differentiation upon challenge. Our results demonstrate that stochastic and instructive events differentially contribute to shaping the primary and secondary CD8+ T cell response and provide insight into the underlying forces that drive effector differentiation and protective memory formation." @default.
- W2084253027 created "2016-06-24" @default.
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- W2084253027 date "2013-08-01" @default.
- W2084253027 modified "2023-10-18" @default.
- W2084253027 title "Environmental Cues Dictate the Fate of Individual CD8+ T Cells Responding to Infection" @default.
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- W2084253027 doi "https://doi.org/10.1016/j.immuni.2013.07.014" @default.
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