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• W2084253895 abstract "Atherosclerosis is a chronic inflammatory disease, characterized by the accumulation of lipids and fibrous elements within the inner‐most layer of the artery wall. Vulnerable atherosclerotic plaques may eventually rupture, resulting in emboli that can obstruct blood flow and result in stroke or myocardial infarction. Direct measurements of atherosclerosis include non‐invasive imaging phenotypes such as MRI and 3DUS derived plaque and wall volume measurements and B‐mode US measurements of the intima media thickness (IMT). Here we report the first comparison of IMT with 3D Ultrasound and MRI‐derived atherosclerosis phenotypes measured in five subjects with moderate carotid atherosclerosis . Five research subjects with carotid plaque area ⩾ 0.5 cm2 were studied and all subjects were undergoing treatment for hyperlipidemia. Mean age was 66 yrs with no significant difference between males and females. Subjects underwent MRI, 3DUS and 2D B‐mode US of the left and right carotid arteries. A single observer carried out 3DUS vessel wall volume measurements (VWV) in 10 subject images at both time points, a second observer measured MRI vessel wall volume; a third observer measured IMT. Both 3DUS VWV and MRI VWV measurements were repeated five times to determine intra‐observer variability and variability between time points. At baseline 3DUS and MRI VWV measurements were not significantly different. No significant differences was observed for mean 3DUS VWV and MRI VWV at test and retest. No significant difference between mean IMT at test and retest was found. IMT measurements had the highest intra‐class correlation coefficients and the lowest coefficient of variation values." @default.
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• W2084253895 date "2006-07-01" @default.
• W2084253895 modified "2023-09-26" @default.
• W2084253895 title "Po-Thur Eve General-24: Non-Invasive Imaging Phenotypes of Carotid Atherosclerosis in Subjects: MRI, B-mode and 3D Ultrasound Measurements" @default.
• W2084253895 doi "https://doi.org/10.1118/1.2244651" @default.
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