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• W2084261305 endingPage "1389" @default.
• W2084261305 startingPage "1380" @default.
• W2084261305 abstract "Gram-positive bacteria surround themselves with a thick cell wall that is essential to cell survival and is a major target of antibiotics. Quantifying alterations in cell-wall composition are crucial to evaluating drug modes of action, particularly important for human pathogens that are now resistant to multiple antibiotics such as Staphylococcus aureus. Macromolecular and whole-cell NMR spectroscopy allowed us to observe the full panel of carbon and nitrogen pools in S. aureus cell walls and intact whole cells. We discovered that one-dimensional 13C and 15N NMR spectra, together with spectroscopic selections based on dipolar couplings as well as two-dimensional spin-diffusion measurements, revealed the dramatic compositional differences between intact cells and cell walls and allowed the identification of cell-wall signatures in whole-cell samples. Furthermore, the whole-cell NMR approach exhibited the sensitivity to detect distinct compositional changes due to treatment with the antibiotics fosfomycin (a cell-wall biosynthesis inhibitor) and chloramphenicol (a protein synthesis inhibitor). Whole cells treated with fosfomycin exhibited decreased peptidoglycan contributions while those treated with chloramphenicol contained a higher percentage of peptidoglycan as cytoplasmic protein content was reduced. Thus, general antibiotic modes of action can be identified by profiling the total carbon pools in intact whole cells." @default.
• W2084261305 created "2016-06-24" @default.
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• W2084261305 date "2015-03-01" @default.
• W2084261305 modified "2023-10-16" @default.
• W2084261305 title "Spectral Snapshots of Bacterial Cell-Wall Composition and the Influence of Antibiotics by Whole-Cell NMR" @default.
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• W2084261305 doi "https://doi.org/10.1016/j.bpj.2015.01.037" @default.
• W2084261305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4375516" @default.
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• W2084261305 hasPublicationYear "2015" @default.
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