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- W2084282354 abstract "Complementing scarce experimental data, we provide computational evidence via all-atom molecular dynamics simulations for conformational changes and dynamical changes induced in the MSH2/6 heterodimer in response to DNA damage induced by platinum-based chemotherapuetics. We demonstrate thay 1,2 and 1,3 intra-strand platinum-DNA adducts are recognized by MutSα in a similar manner, but with subtle differences which may play a role in the way the different damages are signaled by MutSα." @default.
- W2084282354 created "2016-06-24" @default.
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- W2084282354 date "2013-01-01" @default.
- W2084282354 modified "2023-09-27" @default.
- W2084282354 title "Recognition of Chemotherapeutically Damaged DNA by Mismatch Repair Proteins" @default.
- W2084282354 doi "https://doi.org/10.1016/j.bpj.2012.11.413" @default.
- W2084282354 hasPublicationYear "2013" @default.
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