Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084291206> ?p ?o ?g. }
- W2084291206 endingPage "L363" @default.
- W2084291206 startingPage "L355" @default.
- W2084291206 abstract "Sepsis and septic shock lead to considerable morbidity and mortality in developed and developing countries. Despite advances in understanding the innate immune events that lead to septic shock, molecular therapies based on these advances have failed to improve sepsis mortality. The clinical failure of laboratory-derived therapies may be, in part, due to the pleiotropic consequences of the acute inflammatory response, which is the focus of this review. A brisk response to infecting organism is essential for pathogen containment and eradication. However, systemic spread of inflammation beyond a single focus leads to organ injury and higher mortality. The primary goal of this article is to discuss recent animal- and human-based scientific advances in understanding the host response to infection and to highlight how these defense mechanisms can be locally beneficial but systemically detrimental. There are other factors that determine the severity of sepsis that are beyond the scope of this review, including the virulence of the pathogen and regulation by Toll-like receptors. Specifically, this review focuses on how the effector mechanisms of platelets, mast cells, neutrophil extracellular traps (NETs), and the endothelium participate in combating local infections yet can induce organ injury during systemic infection." @default.
- W2084291206 created "2016-06-24" @default.
- W2084291206 creator A5035567835 @default.
- W2084291206 creator A5052576862 @default.
- W2084291206 creator A5062110320 @default.
- W2084291206 date "2012-09-01" @default.
- W2084291206 modified "2023-10-15" @default.
- W2084291206 title "Inflection points in sepsis biology: from local defense to systemic organ injury" @default.
- W2084291206 cites W1487287383 @default.
- W2084291206 cites W1499659307 @default.
- W2084291206 cites W1565635064 @default.
- W2084291206 cites W1600560134 @default.
- W2084291206 cites W1605072661 @default.
- W2084291206 cites W1706591859 @default.
- W2084291206 cites W1854494624 @default.
- W2084291206 cites W1972749969 @default.
- W2084291206 cites W1972950962 @default.
- W2084291206 cites W1976954262 @default.
- W2084291206 cites W1977248022 @default.
- W2084291206 cites W1977331927 @default.
- W2084291206 cites W1978508787 @default.
- W2084291206 cites W1981188731 @default.
- W2084291206 cites W1982169353 @default.
- W2084291206 cites W1986282241 @default.
- W2084291206 cites W1989551786 @default.
- W2084291206 cites W1992245975 @default.
- W2084291206 cites W1992974015 @default.
- W2084291206 cites W1998634876 @default.
- W2084291206 cites W2005966848 @default.
- W2084291206 cites W2006515599 @default.
- W2084291206 cites W2014776493 @default.
- W2084291206 cites W2016385216 @default.
- W2084291206 cites W2022671860 @default.
- W2084291206 cites W2027065937 @default.
- W2084291206 cites W2028188331 @default.
- W2084291206 cites W2033380685 @default.
- W2084291206 cites W2034359425 @default.
- W2084291206 cites W2038434279 @default.
- W2084291206 cites W2042653501 @default.
- W2084291206 cites W2042851093 @default.
- W2084291206 cites W2043183618 @default.
- W2084291206 cites W2045819100 @default.
- W2084291206 cites W2046783872 @default.
- W2084291206 cites W2048801137 @default.
- W2084291206 cites W2050413576 @default.
- W2084291206 cites W2052097550 @default.
- W2084291206 cites W2053071530 @default.
- W2084291206 cites W2057905142 @default.
- W2084291206 cites W2061443292 @default.
- W2084291206 cites W2061514779 @default.
- W2084291206 cites W2063291570 @default.
- W2084291206 cites W2064626913 @default.
- W2084291206 cites W2064799108 @default.
- W2084291206 cites W2065290731 @default.
- W2084291206 cites W2065704006 @default.
- W2084291206 cites W2065965568 @default.
- W2084291206 cites W2068946536 @default.
- W2084291206 cites W2075481151 @default.
- W2084291206 cites W2081166085 @default.
- W2084291206 cites W2082728447 @default.
- W2084291206 cites W2087403378 @default.
- W2084291206 cites W2089266916 @default.
- W2084291206 cites W2089782191 @default.
- W2084291206 cites W2090628166 @default.
- W2084291206 cites W2092522150 @default.
- W2084291206 cites W2094265468 @default.
- W2084291206 cites W2095249660 @default.
- W2084291206 cites W2099629405 @default.
- W2084291206 cites W2101674426 @default.
- W2084291206 cites W2102831728 @default.
- W2084291206 cites W2103835275 @default.
- W2084291206 cites W2104723371 @default.
- W2084291206 cites W2104825124 @default.
- W2084291206 cites W2104934425 @default.
- W2084291206 cites W2108396254 @default.
- W2084291206 cites W2108729511 @default.
- W2084291206 cites W2110971703 @default.
- W2084291206 cites W2111727066 @default.
- W2084291206 cites W2124013425 @default.
- W2084291206 cites W2128062438 @default.
- W2084291206 cites W2129339954 @default.
- W2084291206 cites W2134219545 @default.
- W2084291206 cites W2135492318 @default.
- W2084291206 cites W2136082432 @default.
- W2084291206 cites W2137082708 @default.
- W2084291206 cites W2141868068 @default.
- W2084291206 cites W2142264873 @default.
- W2084291206 cites W2143886761 @default.
- W2084291206 cites W2148336324 @default.
- W2084291206 cites W2149772482 @default.
- W2084291206 cites W2155219561 @default.
- W2084291206 cites W2155433658 @default.
- W2084291206 cites W2157415059 @default.
- W2084291206 cites W2160053026 @default.
- W2084291206 cites W2161666019 @default.
- W2084291206 cites W2163240112 @default.
- W2084291206 cites W2166019746 @default.
- W2084291206 cites W2167377974 @default.