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• W2084293211 endingPage "1751" @default.
• W2084293211 startingPage "1745" @default.
• W2084293211 abstract "The absorption, distribution, metabolism, and excretion of volatile organic compounds (VOCs) are critically determined by a few chemical-specific factors, notably their blood and tissue partition coefficients (PC) and metabolism. Age-specific values for PCs in rats have rarely been reported or utilized in pharmacokinetic modeling for predicting dosimetry in toxicity studies with rats progressing through their lifestages. A mixture of six VOCs (benzene, chloroform, methyl ethyl ketone, methylene chloride, trichloroethylene, and perchloroethylene) was used to determine blood:air and tissue:air PCs in rats at three different ages (postnatal d 10, 60 d, and 2 yr) and blood:air PCs in pediatric and adult human blood. No differences with age in human blood:air PCs for the six compounds were observed. Rat blood:air PCs increased with age varying with compound. Tissue:air PCs showed tissue-specific changes with age. Water-soluble methyl ethyl ketone showed no age-dependent differences. Partition coefficients, particularly the blood:air PC, are key determinants of the rodent and human blood concentrations; age-appropriate values improve the accuracy of pharmacokinetic model predictions of population variability and age-specific exposures." @default.
• W2084293211 created "2016-06-24" @default.
• W2084293211 creator A5009267295 @default.
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• W2084293211 date "2007-09-13" @default.
• W2084293211 modified "2023-10-05" @default.
• W2084293211 title "Age-Dependent Partition Coefficients for a Mixture of Volatile Organic Solvents in Sprague-Dawley Rats and Humans" @default.
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• W2084293211 doi "https://doi.org/10.1080/15287390701458991" @default.
• W2084293211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17885931" @default.
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