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- W2084312877 abstract "Several lines of evidence suggest an impairment of mitochondrial function in the brain of patients with Parkinson's disease (PD). However, the presence of a detectable mitochondrial defect in extracerebral tissue of these patients remains a matter of dispute. Therefore, we investigated mitochondrial function in fibroblasts of 18 PD patients applying biochemical micromethods. Putative beneficial effects of coenzyme Q10 (CoQ10), a potent antioxidant, on the mitochondrial function of skin fibroblast cultures were evaluated. Applying inhibitor titrations of the mitochondrial respiration to calculate flux control coefficients of respiratory chain complexes I and IV, we observed deficiencies of both complexes in cultivated skin fibroblasts of PD patients. Cultivation of fibroblasts in the presence of 5 μM CoQ10 restored the activity of impaired respiratory chain complexes in the fibroblast cultures of 9 out of 18 PD patients. Our data support the presence of a generalised mitochondrial defect in at least a subgroup of patients with PD that can be partially ameliorated in vitro by coenzyme Q10 treatment." @default.
- W2084312877 created "2016-06-24" @default.
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- W2084312877 date "2004-05-01" @default.
- W2084312877 modified "2023-10-18" @default.
- W2084312877 title "Effect of coenzyme Q10 on the mitochondrial function of skin fibroblasts from Parkinson patients" @default.
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- W2084312877 doi "https://doi.org/10.1016/j.jns.2004.02.003" @default.
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