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- W2084313995 abstract "Two unidentified arsenic metabolites were detected in the liver of rats on a gel filtration column by HPLC inductively coupled argon plasma mass spectrometry after an injection of dimethylarsinic (DMAV), dimethylarsinous (DMAIII), monomethylarsonic (MMAV), or monomethylarsonous (MMAIII) acid. The same arsenicals were also produced in vitro by incubation of DMAIII in the liver supernatant but not by DMAV. The two arsenic metabolites eluted at the same retention times as those of the two arsenicals prepared by reaction of DMAV with either thiosulfate plus disulfite or hydrogen sulfide or sodium sulfide plus sulfuric acid. The faster and slower eluting products on a gel filtration column were assigned as dimethyldithioarsinic acid (dimethylarsinodithioic acid) (DMTAV) and dimethylthioarsinous acid (DMTAIII) from mass spectrometric data at m/z = 170 and 138 by electrospray ionization mass spectrometry with negative and positive ion modes, respectively. They were prepared selectively by reacting DMAV with hydrogen sulfide or sodium sulfide plus sulfuric acid under different reaction conditions. DMAIII but not DMAV was transformed to DMTAIII and DMTAV in the presence of sodium sulfide in vitro, suggesting that DMAV is reduced to DMAIII with hydrogen sulfide, thiolated to DMTAIII, and then further thiolated oxidatively to DMTAV. Metabolically, it is assumed that DMAIII is transformed to DMTAIII in the presence of sulfide ions, and then, DMTAIII is oxidatively thiolated to DMTAV. As the chemical species produced by reduction with the Reay and Asher method are DMTAIII and DMTAV, and different from DMAIII, the studies carried out with DMAIII with the Reay and Asher method have to be reexamined." @default.
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- W2084313995 date "2004-06-10" @default.
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- W2084313995 title "Dimethylthioarsenicals as Arsenic Metabolites and Their Chemical Preparations" @default.
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- W2084313995 doi "https://doi.org/10.1021/tx049963s" @default.
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