FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084329639> ?p ?o ?g. }

• W2084329639 endingPage "273" @default.
• W2084329639 startingPage "266" @default.
• W2084329639 abstract "Background: Oral administration of an antigen has been shown to suppress the specific immune response to this antigen. This approach, called oral tolerance, has been demonstrated with intact proteins in animal models for prevention of allergy and autoimmune diseases. Objective: The purpose of this study was to determine whether oral tolerance can be induced with protein peptides. Partially hydrolyzed and extensively hydrolyzed cow's milk formulas were compared for their capacity to induce tolerance to cow's milk proteins. Methods: Five-week-old Sprague-Dawley rats were fed cow's milk formulas ad libitum from day 1 to day 19. All animals were immunized with β-lactoglobulin and ovalbumin on day 5 and bled on day 19. Sera were analyzed for specific IgE and IgG antibodies by ELISA and for functional IgE response by in vitro mast cell mediator (tritiated serotonin) release. In vivo modulation of intestinal mast cells was analyzed by the specific release of the rat mast cell protease II, and T-cell response was determined by tritiated thymidine incorporation into lymph node lymphocytes. Results: Oral administration of a partially hydrolyzed cow's milk formula suppresses specific serum IgE and IgG anti-β-lactoglobulin antibodies, as well as mediator release from rat mast cells and T-lymphocyte response. This suppression was shown to be antigen-specific and dose-dependent. An extensively hydrolyzed formula was unable to achieve the induction of such an oral tolerance. Conclusion: These results support the view that partially hydrolyzed proteins are able to induce specific oral tolerance, whereas extensively hydrolyzed proteins are not. (J Allergy Clin Immunol 1997;100:266-73.)" @default.
• W2084329639 created "2016-06-24" @default.
• W2084329639 creator A5064366381 @default.
• W2084329639 creator A5067864000 @default.
• W2084329639 creator A5072815269 @default.
• W2084329639 creator A5080602878 @default.
• W2084329639 date "1997-08-01" @default.
• W2084329639 modified "2023-10-09" @default.
• W2084329639 title "Induction of systemic immunologic tolerance to β-lactoglobulin by oral administration of a whey protein hydrolysate" @default.
• W2084329639 cites W1579431146 @default.
• W2084329639 cites W1589746940 @default.
• W2084329639 cites W1606951746 @default.
• W2084329639 cites W1979387826 @default.
• W2084329639 cites W1982863911 @default.
• W2084329639 cites W2002003044 @default.
• W2084329639 cites W2018460760 @default.
• W2084329639 cites W2023263940 @default.
• W2084329639 cites W202393495 @default.
• W2084329639 cites W2045918020 @default.
• W2084329639 cites W2058092366 @default.
• W2084329639 cites W2059333131 @default.
• W2084329639 cites W2075376701 @default.
• W2084329639 cites W2077397102 @default.
• W2084329639 cites W2092676860 @default.
• W2084329639 cites W2115790644 @default.
• W2084329639 cites W2136135274 @default.
• W2084329639 cites W2165679543 @default.
• W2084329639 cites W218091235 @default.
• W2084329639 cites W2281389385 @default.
• W2084329639 cites W2395660240 @default.
• W2084329639 cites W292699820 @default.
• W2084329639 cites W312186253 @default.
• W2084329639 doi "https://doi.org/10.1016/s0091-6749(97)70235-5" @default.
• W2084329639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9275151" @default.
• W2084329639 hasPublicationYear "1997" @default.
• W2084329639 type Work @default.
• W2084329639 sameAs 2084329639 @default.
• W2084329639 citedByCount "99" @default.
• W2084329639 countsByYear W20843296392012 @default.
• W2084329639 countsByYear W20843296392013 @default.
• W2084329639 countsByYear W20843296392014 @default.
• W2084329639 countsByYear W20843296392015 @default.
• W2084329639 countsByYear W20843296392016 @default.
• W2084329639 countsByYear W20843296392017 @default.
• W2084329639 countsByYear W20843296392018 @default.
• W2084329639 countsByYear W20843296392019 @default.
• W2084329639 countsByYear W20843296392020 @default.
• W2084329639 countsByYear W20843296392021 @default.
• W2084329639 countsByYear W20843296392022 @default.
• W2084329639 countsByYear W20843296392023 @default.
• W2084329639 crossrefType "journal-article" @default.
• W2084329639 hasAuthorship W2084329639A5064366381 @default.
• W2084329639 hasAuthorship W2084329639A5067864000 @default.
• W2084329639 hasAuthorship W2084329639A5072815269 @default.
• W2084329639 hasAuthorship W2084329639A5080602878 @default.
• W2084329639 hasConcept C141105273 @default.
• W2084329639 hasConcept C147483822 @default.
• W2084329639 hasConcept C159654299 @default.
• W2084329639 hasConcept C185592680 @default.
• W2084329639 hasConcept C203014093 @default.
• W2084329639 hasConcept C2776946954 @default.
• W2084329639 hasConcept C2776953665 @default.
• W2084329639 hasConcept C2777056448 @default.
• W2084329639 hasConcept C2777702733 @default.
• W2084329639 hasConcept C2779726688 @default.
• W2084329639 hasConcept C28800991 @default.
• W2084329639 hasConcept C55493867 @default.
• W2084329639 hasConcept C71924100 @default.
• W2084329639 hasConcept C8891405 @default.
• W2084329639 hasConcept C94412978 @default.
• W2084329639 hasConcept C98274493 @default.
• W2084329639 hasConceptScore W2084329639C141105273 @default.
• W2084329639 hasConceptScore W2084329639C147483822 @default.
• W2084329639 hasConceptScore W2084329639C159654299 @default.
• W2084329639 hasConceptScore W2084329639C185592680 @default.
• W2084329639 hasConceptScore W2084329639C203014093 @default.
• W2084329639 hasConceptScore W2084329639C2776946954 @default.
• W2084329639 hasConceptScore W2084329639C2776953665 @default.
• W2084329639 hasConceptScore W2084329639C2777056448 @default.
• W2084329639 hasConceptScore W2084329639C2777702733 @default.
• W2084329639 hasConceptScore W2084329639C2779726688 @default.
• W2084329639 hasConceptScore W2084329639C28800991 @default.
• W2084329639 hasConceptScore W2084329639C55493867 @default.
• W2084329639 hasConceptScore W2084329639C71924100 @default.
• W2084329639 hasConceptScore W2084329639C8891405 @default.
• W2084329639 hasConceptScore W2084329639C94412978 @default.
• W2084329639 hasConceptScore W2084329639C98274493 @default.
• W2084329639 hasIssue "2" @default.
• W2084329639 hasLocation W20843296391 @default.
• W2084329639 hasLocation W20843296392 @default.
• W2084329639 hasOpenAccess W2084329639 @default.
• W2084329639 hasPrimaryLocation W20843296391 @default.
• W2084329639 hasRelatedWork W1922154875 @default.
• W2084329639 hasRelatedWork W1987724372 @default.
• W2084329639 hasRelatedWork W2007435219 @default.
• W2084329639 hasRelatedWork W2046654069 @default.
• W2084329639 hasRelatedWork W2064333212 @default.
• W2084329639 hasRelatedWork W2601156958 @default.

• next