FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084334125> ?p ?o ?g. }

• W2084334125 endingPage "1811" @default.
• W2084334125 startingPage "1801" @default.
• W2084334125 abstract "In contrast to the well-established relationship between cadherins and the actin cytoskeleton, the potential link between cadherins and microtubules (MTs) has been less extensively investigated. We now identify a pool of MTs that extend radially into cell-cell contacts and are inhibited by manoeuvres that block the dynamic activity of MT plus-ends (e.g. in the presence of low concentrations of nocodazole and following expression of a CLIP-170 mutant). Blocking dynamic MTs perturbed the ability of cells to concentrate and accumulate E-cadherin at cell-cell contacts, as assessed both by quantitative immunofluorescence microscopy and fluorescence recovery after photobleaching (FRAP) analysis, but did not affect either transport of E-cadherin to the plasma membrane or the amount of E-cadherin expressed at the cell surface. This indicated that dynamic MTs allow cells to concentrate E-cadherin at cell-cell contacts by regulating the regional distribution of E-cadherin once it reaches the cell surface. Importantly, dynamic MTs were necessary for myosin II to accumulate and be activated at cadherin adhesive contacts, a mechanism that supports the focal accumulation of E-cadherin. We propose that this population of MTs represents a novel form of cadherin-MT cooperation, where cadherin adhesions recruit dynamic MTs that, in turn, support the local concentration of cadherin molecules by regulating myosin II activity at cell-cell contacts." @default.
• W2084334125 created "2016-06-24" @default.
• W2084334125 creator A5002574488 @default.
• W2084334125 creator A5005036509 @default.
• W2084334125 creator A5009751579 @default.
• W2084334125 creator A5018589365 @default.
• W2084334125 creator A5019567999 @default.
• W2084334125 creator A5029211283 @default.
• W2084334125 creator A5032960507 @default.
• W2084334125 creator A5040978306 @default.
• W2084334125 date "2006-05-01" @default.
• W2084334125 modified "2023-10-17" @default.
• W2084334125 title "Dynamic microtubules regulate the local concentration of E-cadherin at cell-cell contacts" @default.
• W2084334125 cites W124246603 @default.
• W2084334125 cites W1550148342 @default.
• W2084334125 cites W1594528382 @default.
• W2084334125 cites W1744742580 @default.
• W2084334125 cites W1973466009 @default.
• W2084334125 cites W1987704865 @default.
• W2084334125 cites W1989170923 @default.
• W2084334125 cites W1991976042 @default.
• W2084334125 cites W1992299767 @default.
• W2084334125 cites W1997986612 @default.
• W2084334125 cites W2004280410 @default.
• W2084334125 cites W2008920115 @default.
• W2084334125 cites W2009671568 @default.
• W2084334125 cites W2021135236 @default.
• W2084334125 cites W2029611078 @default.
• W2084334125 cites W2032100189 @default.
• W2084334125 cites W2034341872 @default.
• W2084334125 cites W2041158925 @default.
• W2084334125 cites W2046560218 @default.
• W2084334125 cites W2046643533 @default.
• W2084334125 cites W2049793641 @default.
• W2084334125 cites W2049918202 @default.
• W2084334125 cites W2050193685 @default.
• W2084334125 cites W2053959232 @default.
• W2084334125 cites W2062927800 @default.
• W2084334125 cites W2065131699 @default.
• W2084334125 cites W2067606503 @default.
• W2084334125 cites W2072509928 @default.
• W2084334125 cites W2078862404 @default.
• W2084334125 cites W2086061027 @default.
• W2084334125 cites W2090304998 @default.
• W2084334125 cites W2098159442 @default.
• W2084334125 cites W2102877711 @default.
• W2084334125 cites W2107985768 @default.
• W2084334125 cites W2109016302 @default.
• W2084334125 cites W2113628986 @default.
• W2084334125 cites W2121515452 @default.
• W2084334125 cites W2124016864 @default.
• W2084334125 cites W2126904219 @default.
• W2084334125 cites W2132629429 @default.
• W2084334125 cites W2150148805 @default.
• W2084334125 cites W2154968967 @default.
• W2084334125 cites W2156419662 @default.
• W2084334125 cites W4252027219 @default.
• W2084334125 doi "https://doi.org/10.1242/jcs.02903" @default.
• W2084334125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16608875" @default.
• W2084334125 hasPublicationYear "2006" @default.
• W2084334125 type Work @default.
• W2084334125 sameAs 2084334125 @default.
• W2084334125 citedByCount "167" @default.
• W2084334125 countsByYear W20843341252012 @default.
• W2084334125 countsByYear W20843341252013 @default.
• W2084334125 countsByYear W20843341252014 @default.
• W2084334125 countsByYear W20843341252015 @default.
• W2084334125 countsByYear W20843341252016 @default.
• W2084334125 countsByYear W20843341252017 @default.
• W2084334125 countsByYear W20843341252018 @default.
• W2084334125 countsByYear W20843341252019 @default.
• W2084334125 countsByYear W20843341252020 @default.
• W2084334125 countsByYear W20843341252021 @default.
• W2084334125 countsByYear W20843341252022 @default.
• W2084334125 countsByYear W20843341252023 @default.
• W2084334125 crossrefType "journal-article" @default.
• W2084334125 hasAuthorship W2084334125A5002574488 @default.
• W2084334125 hasAuthorship W2084334125A5005036509 @default.
• W2084334125 hasAuthorship W2084334125A5009751579 @default.
• W2084334125 hasAuthorship W2084334125A5018589365 @default.
• W2084334125 hasAuthorship W2084334125A5019567999 @default.
• W2084334125 hasAuthorship W2084334125A5029211283 @default.
• W2084334125 hasAuthorship W2084334125A5032960507 @default.
• W2084334125 hasAuthorship W2084334125A5040978306 @default.
• W2084334125 hasBestOaLocation W20843341251 @default.
• W2084334125 hasConcept C125705527 @default.
• W2084334125 hasConcept C142669718 @default.
• W2084334125 hasConcept C144024400 @default.
• W2084334125 hasConcept C1491633281 @default.
• W2084334125 hasConcept C149402561 @default.
• W2084334125 hasConcept C149923435 @default.
• W2084334125 hasConcept C183521119 @default.
• W2084334125 hasConcept C20418707 @default.
• W2084334125 hasConcept C26659971 @default.
• W2084334125 hasConcept C2776041460 @default.
• W2084334125 hasConcept C2779363559 @default.
• W2084334125 hasConcept C2908647359 @default.
• W2084334125 hasConcept C41625074 @default.

• next