FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084346517> ?p ?o ?g. }

• W2084346517 endingPage "508" @default.
• W2084346517 startingPage "496" @default.
• W2084346517 abstract "Stereocilia, finger-like projections forming the hair bundle on the apical surface of sensory hair cells in the cochlea, are responsible for mechanosensation and ultimately the perception of sound. The actin cytoskeleton of the stereocilia contains hundreds of tightly cross-linked parallel actin filaments in a paracrystalline array and it is vital for their function. Although several genes have been identified and associated with stereocilia development, the molecular mechanisms responsible for stereocilia growth, maintenance and organisation of the hair bundle have not been fully resolved. Here we provide further characterisation of the stereocilia of the whirler mouse mutant. We found that a lack of whirlin protein in whirler mutants results in short stereocilia with larger diameters without a corresponding increase in the number of actin filaments in inner hair cells. However, a decrease in the actin filament packing density was evident in the whirler mutant. The electron-density at the tip of each stereocilium was markedly patchy and irregular in the whirler mutants compared with a uniform band in controls. The outer hair cell stereocilia of the whirler homozygote also showed an increase in diameter and variable heights within bundles. The number of outer hair cell stereocilia was significantly reduced and the centre-to-centre spacing between the stereocilia was greater than in the wildtype. Our findings suggest that whirlin plays an important role in actin filament packing and dynamics during postnatal stereocilium elongation. Cell Motil. Cytoskeleton 2007. © 2007 Wiley-Liss, Inc." @default.
• W2084346517 created "2016-06-24" @default.
• W2084346517 creator A5023941735 @default.
• W2084346517 creator A5061140227 @default.
• W2084346517 creator A5068417036 @default.
• W2084346517 date "2007-01-01" @default.
• W2084346517 modified "2023-09-24" @default.
• W2084346517 title "The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development" @default.
• W2084346517 cites W12432200 @default.
• W2084346517 cites W1497847138 @default.
• W2084346517 cites W1552845688 @default.
• W2084346517 cites W1596903488 @default.
• W2084346517 cites W1969248093 @default.
• W2084346517 cites W1979699018 @default.
• W2084346517 cites W1986076446 @default.
• W2084346517 cites W1994337224 @default.
• W2084346517 cites W2003521480 @default.
• W2084346517 cites W2014313116 @default.
• W2084346517 cites W2015903323 @default.
• W2084346517 cites W2019924758 @default.
• W2084346517 cites W2023474594 @default.
• W2084346517 cites W2059790898 @default.
• W2084346517 cites W2065443989 @default.
• W2084346517 cites W2068534775 @default.
• W2084346517 cites W2080377358 @default.
• W2084346517 cites W2084096953 @default.
• W2084346517 cites W2096220987 @default.
• W2084346517 cites W2130717810 @default.
• W2084346517 cites W2130986890 @default.
• W2084346517 cites W2141036744 @default.
• W2084346517 cites W2143405346 @default.
• W2084346517 cites W2146894615 @default.
• W2084346517 cites W2151315634 @default.
• W2084346517 cites W2153404919 @default.
• W2084346517 cites W2154874402 @default.
• W2084346517 cites W2155652989 @default.
• W2084346517 cites W2162644119 @default.
• W2084346517 cites W2325112351 @default.
• W2084346517 cites W4252423694 @default.
• W2084346517 doi "https://doi.org/10.1002/cm.20199" @default.
• W2084346517 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2682331" @default.
• W2084346517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17326148" @default.
• W2084346517 hasPublicationYear "2007" @default.
• W2084346517 type Work @default.
• W2084346517 sameAs 2084346517 @default.
• W2084346517 citedByCount "47" @default.
• W2084346517 countsByYear W20843465172012 @default.
• W2084346517 countsByYear W20843465172013 @default.
• W2084346517 countsByYear W20843465172014 @default.
• W2084346517 countsByYear W20843465172015 @default.
• W2084346517 countsByYear W20843465172016 @default.
• W2084346517 countsByYear W20843465172017 @default.
• W2084346517 countsByYear W20843465172018 @default.
• W2084346517 countsByYear W20843465172019 @default.
• W2084346517 countsByYear W20843465172020 @default.
• W2084346517 countsByYear W20843465172021 @default.
• W2084346517 countsByYear W20843465172022 @default.
• W2084346517 countsByYear W20843465172023 @default.
• W2084346517 crossrefType "journal-article" @default.
• W2084346517 hasAuthorship W2084346517A5023941735 @default.
• W2084346517 hasAuthorship W2084346517A5061140227 @default.
• W2084346517 hasAuthorship W2084346517A5068417036 @default.
• W2084346517 hasBestOaLocation W20843465171 @default.
• W2084346517 hasConcept C104317684 @default.
• W2084346517 hasConcept C105702510 @default.
• W2084346517 hasConcept C12554922 @default.
• W2084346517 hasConcept C125705527 @default.
• W2084346517 hasConcept C14228908 @default.
• W2084346517 hasConcept C142669718 @default.
• W2084346517 hasConcept C143065580 @default.
• W2084346517 hasConcept C1491633281 @default.
• W2084346517 hasConcept C2776557274 @default.
• W2084346517 hasConcept C2778500370 @default.
• W2084346517 hasConcept C2778585322 @default.
• W2084346517 hasConcept C2780130748 @default.
• W2084346517 hasConcept C2993400109 @default.
• W2084346517 hasConcept C54355233 @default.
• W2084346517 hasConcept C86803240 @default.
• W2084346517 hasConcept C95444343 @default.
• W2084346517 hasConceptScore W2084346517C104317684 @default.
• W2084346517 hasConceptScore W2084346517C105702510 @default.
• W2084346517 hasConceptScore W2084346517C12554922 @default.
• W2084346517 hasConceptScore W2084346517C125705527 @default.
• W2084346517 hasConceptScore W2084346517C14228908 @default.
• W2084346517 hasConceptScore W2084346517C142669718 @default.
• W2084346517 hasConceptScore W2084346517C143065580 @default.
• W2084346517 hasConceptScore W2084346517C1491633281 @default.
• W2084346517 hasConceptScore W2084346517C2776557274 @default.
• W2084346517 hasConceptScore W2084346517C2778500370 @default.
• W2084346517 hasConceptScore W2084346517C2778585322 @default.
• W2084346517 hasConceptScore W2084346517C2780130748 @default.
• W2084346517 hasConceptScore W2084346517C2993400109 @default.
• W2084346517 hasConceptScore W2084346517C54355233 @default.
• W2084346517 hasConceptScore W2084346517C86803240 @default.
• W2084346517 hasConceptScore W2084346517C95444343 @default.
• W2084346517 hasIssue "7" @default.
• W2084346517 hasLocation W20843465171 @default.
• W2084346517 hasLocation W20843465172 @default.

• next