Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084347027> ?p ?o ?g. }
- W2084347027 endingPage "946" @default.
- W2084347027 startingPage "934" @default.
- W2084347027 abstract "Intracellular analysis has been shown to be useful as a tool for control production processes based on in vitro cultivated hybridoma and recombinant animal cells. Nucleotides were found to present the best target as they reflect the exact physiological state of a culture. Following the progress of batch, perfused, and chemostat cultures cell specific regularities were found in various biochemical correlations which allowed the generation of three characteristic parameters based on the interaction of particular nucleotides: the nucleotide triphosphate (NTP) ratio ([ATP + GTP]/[UTP + CTP]), the uridine (U) ratio (UTP/UDP-GNAc), and the combined ratio NTP/U ([UDP-GNAc (ATP + GTP)/ UTP (UTP + CTP)]). These allowed a direct description of the growth cycle by means of specific values or behavior for every phase of the culture. In particular, the critical phase of entrance into the phase of reduced growth was predicted up to 24 h earlier than was possible with the classical method of microscopic cell control. A specific function for the application of in vitro cultivated processes is proposed with an NTP-to-U plot which combines the results obtained by the cell analysis and which offers a tool for the control and regulation of cell growth-derived procedures." @default.
- W2084347027 created "2016-06-24" @default.
- W2084347027 creator A5005576534 @default.
- W2084347027 creator A5065065109 @default.
- W2084347027 date "1992-10-20" @default.
- W2084347027 modified "2023-09-26" @default.
- W2084347027 title "Intracellular ribonucleotide pools as a tool for monitoring the physiological state of in vitro cultivated mammalian cells during production processes" @default.
- W2084347027 cites W100704323 @default.
- W2084347027 cites W106190026 @default.
- W2084347027 cites W1506157243 @default.
- W2084347027 cites W1506815516 @default.
- W2084347027 cites W1579051060 @default.
- W2084347027 cites W1988520403 @default.
- W2084347027 cites W1995204382 @default.
- W2084347027 cites W2012506922 @default.
- W2084347027 cites W2013051900 @default.
- W2084347027 cites W2013276474 @default.
- W2084347027 cites W2017533728 @default.
- W2084347027 cites W2025322681 @default.
- W2084347027 cites W2030522563 @default.
- W2084347027 cites W2032272422 @default.
- W2084347027 cites W2045640384 @default.
- W2084347027 cites W2053072959 @default.
- W2084347027 cites W2072573383 @default.
- W2084347027 cites W2094453144 @default.
- W2084347027 cites W2100662953 @default.
- W2084347027 cites W2246930769 @default.
- W2084347027 cites W2267276162 @default.
- W2084347027 cites W2314459201 @default.
- W2084347027 cites W3013624173 @default.
- W2084347027 cites W939009159 @default.
- W2084347027 doi "https://doi.org/10.1002/bit.260400810" @default.
- W2084347027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18601201" @default.
- W2084347027 hasPublicationYear "1992" @default.
- W2084347027 type Work @default.
- W2084347027 sameAs 2084347027 @default.
- W2084347027 citedByCount "58" @default.
- W2084347027 countsByYear W20843470272012 @default.
- W2084347027 countsByYear W20843470272013 @default.
- W2084347027 countsByYear W20843470272014 @default.
- W2084347027 countsByYear W20843470272015 @default.
- W2084347027 countsByYear W20843470272016 @default.
- W2084347027 countsByYear W20843470272017 @default.
- W2084347027 crossrefType "journal-article" @default.
- W2084347027 hasAuthorship W2084347027A5005576534 @default.
- W2084347027 hasAuthorship W2084347027A5065065109 @default.
- W2084347027 hasConcept C104317684 @default.
- W2084347027 hasConcept C118716 @default.
- W2084347027 hasConcept C125111812 @default.
- W2084347027 hasConcept C12554922 @default.
- W2084347027 hasConcept C181199279 @default.
- W2084347027 hasConcept C202751555 @default.
- W2084347027 hasConcept C2776638253 @default.
- W2084347027 hasConcept C2778564976 @default.
- W2084347027 hasConcept C2781259782 @default.
- W2084347027 hasConcept C512185932 @default.
- W2084347027 hasConcept C523546767 @default.
- W2084347027 hasConcept C54355233 @default.
- W2084347027 hasConcept C55493867 @default.
- W2084347027 hasConcept C67705224 @default.
- W2084347027 hasConcept C79879829 @default.
- W2084347027 hasConcept C81885089 @default.
- W2084347027 hasConcept C86803240 @default.
- W2084347027 hasConcept C95444343 @default.
- W2084347027 hasConcept C98892162 @default.
- W2084347027 hasConceptScore W2084347027C104317684 @default.
- W2084347027 hasConceptScore W2084347027C118716 @default.
- W2084347027 hasConceptScore W2084347027C125111812 @default.
- W2084347027 hasConceptScore W2084347027C12554922 @default.
- W2084347027 hasConceptScore W2084347027C181199279 @default.
- W2084347027 hasConceptScore W2084347027C202751555 @default.
- W2084347027 hasConceptScore W2084347027C2776638253 @default.
- W2084347027 hasConceptScore W2084347027C2778564976 @default.
- W2084347027 hasConceptScore W2084347027C2781259782 @default.
- W2084347027 hasConceptScore W2084347027C512185932 @default.
- W2084347027 hasConceptScore W2084347027C523546767 @default.
- W2084347027 hasConceptScore W2084347027C54355233 @default.
- W2084347027 hasConceptScore W2084347027C55493867 @default.
- W2084347027 hasConceptScore W2084347027C67705224 @default.
- W2084347027 hasConceptScore W2084347027C79879829 @default.
- W2084347027 hasConceptScore W2084347027C81885089 @default.
- W2084347027 hasConceptScore W2084347027C86803240 @default.
- W2084347027 hasConceptScore W2084347027C95444343 @default.
- W2084347027 hasConceptScore W2084347027C98892162 @default.
- W2084347027 hasIssue "8" @default.
- W2084347027 hasLocation W20843470271 @default.
- W2084347027 hasLocation W20843470272 @default.
- W2084347027 hasOpenAccess W2084347027 @default.
- W2084347027 hasPrimaryLocation W20843470271 @default.
- W2084347027 hasRelatedWork W10414247 @default.
- W2084347027 hasRelatedWork W1771043215 @default.
- W2084347027 hasRelatedWork W2018779821 @default.
- W2084347027 hasRelatedWork W2061632319 @default.
- W2084347027 hasRelatedWork W2069062978 @default.
- W2084347027 hasRelatedWork W2084347027 @default.
- W2084347027 hasRelatedWork W2105689639 @default.
- W2084347027 hasRelatedWork W2275053380 @default.
- W2084347027 hasRelatedWork W2330031492 @default.