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• W2084351458 abstract "Chromosome congression is the alignment of chromosomes at the spindle equator, and is a prerequisite for faithful chromosome segregation. Recent data suggest that before kinetochores attach to the end of microtubules (end-on attachment), chromosomes can move along microtubules towards the spindle equator through attachment of kinetochores to the lateral surface of microtubules (lateral attachment). Here we address this mechanism, focusing on the contribution of two mitotic motors, Kid and CENP-E. In cells depleted of Hec1, which is essential for end-on attachment, chromosomes show partial and transient congression. This transient congression is further perturbed by co-depletion of Kid, suggesting its role in chromosome congression. In comparison, CENP-E suppresses chromosome congression, probably by tethering kinetochores to short, unstable microtubules, and works in congression only when microtubules are stabilized. Our results may reflect the differential contributions of Kid and CENP-E in chromosome congression in physiological conditions where stabilized microtubules are becoming increased. Alignment of chromosomes at the spindle equator involves two kinesin family molecular motors, Kid and CENP-E. Here, Iemura and Tanaka show differential contributions of these motors, whereby Kid promotes partial alignment before end-on microtubule attachment to chromosomes, and CENP-E promotes alignment when microtubules are stabilized." @default.
• W2084351458 created "2016-06-24" @default.
• W2084351458 creator A5026658468 @default.
• W2084351458 creator A5058617909 @default.
• W2084351458 date "2015-03-06" @default.
• W2084351458 modified "2023-10-15" @default.
• W2084351458 title "Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules" @default.
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• W2084351458 doi "https://doi.org/10.1038/ncomms7447" @default.
• W2084351458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25743205" @default.
• W2084351458 hasPublicationYear "2015" @default.
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