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- W2084352012 abstract "Our previous studies indicate that function of ATP-dependent K + channels (K ATP ) in cerebral arterioles is suppressed after ischemia. In the current study, we examined pial arteriolar responses to forskolin, dibutyryl-cAMP, NS-1619, and methionine (met)-enkephalin, activators of calcium-dependent K + channels (K Ca ) before and 1 hour after 10 minutes of total, global ischemia in anesthetized piglets. Arteriolar diameters were measured using a closed cranial window and intravital microscopy. All pharmacologic agents were given topically. Baseline diameters were approximately 100 μm, and diameters had returned to normal by 1 hour after ischemia. Forskolin dilated arterioles by 9 ± 3%, 18 ± 4%, and 31 ± 12% at 5 × 10 −8 , 5 × 10 −7 , and 10 −6 mol/L, respectively ( P < 0.05, n = 10). In addition, dibutyryl-cAMP dilated arterioles by 8 ± 2% at 10 −4 mol/L and 14 ± 2% at 3 × 10 −4 mol/L ( P < 0.05, n = 6). Also, NS-1619 increased diameter of arterioles by 9 ± 2% at 10 −7 mol/L and 17 ± 9% at 10 −5 mol/L ( P < 0.05, n = 5). Finally, met-enkephalin dilated arterioles by 9 ± 2% at 10 −8 mol/L and 16 ± 3% at 10 −6 mol/L ( P < 0.05, n = 5). At 1 hour after ischemia, arteriolar dilator effects to forskolin, dibutyryl-cAMP and NS-1619, and met-enkephalin were intact. Thus, in contrast to K ATP , K Ca in cerebral arterioles are resistant to ischemic stress." @default.
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- W2084352012 date "1997-11-01" @default.
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- W2084352012 title "Calcium-Activated K<sup>+</sup> Channels in Cerebral Arterioles in Piglets are Resistant to Ischemia" @default.
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- W2084352012 doi "https://doi.org/10.1097/00004647-199711000-00003" @default.
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