FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084355655> ?p ?o ?g. }

• W2084355655 endingPage "S148" @default.
• W2084355655 startingPage "S148" @default.
• W2084355655 abstract "ObjectivePrior studies have suggested that paternity may be associated with reduced prostate cancer (PCa) risk. Interpretation of these studies has been difficult given that none have considered potential confounding by other risk factors for PCa such as PSA screening, race, and family history of cancer. We sought to determine the independent association of fatherhood with PCa.DesignPopulation-based case-control study.Materials and methodsParticipants from two population-based case-control studies of PCa were studied. Incident cases of PCa in King County, WA were identified from the SEER cancer registry. Controls were frequency matched by age and identified by random digit dialing. Number of children fathered was determined by self-report. A history of clinical infertility was queried among a subset of study participants. PCa risk associated with fatherhood and infertility was assessed with multivariate logistic regression.ResultsData from 1,645 cases of PCa and 1,754 controls were analyzed. There was no substantial difference in the proportion of cases and controls who reported never fathering a child (12.9% and 14.3%, respectively, P=0.34). Age-adjusted analyses showed that compared to those with zero or one child, men who fathered two or more children had a non-significant 13% reduction in prostate cancer risk (adjusted OR 0.87, 95% CI 0.74-1.02; P=0.09). Men who reported a history of infertility had a non-significant increase in PCa risk relative to those who did not (adjusted OR 1.29, 95% CI 0.96 – 1.73; P=0.1). Further adjustment for PSA screening, family history of PCa, marital status and vasectomy status did not significantly change risk estimates.ConclusionFathering two or more children was associated with a modest reduction in the relative risk of PCa, while a history of clinical infertility was associated with an increased relative risk of PCa in this population-based study. Further study of the association between paternity, male infertility and subsequent risk of prostate cancer is warranted. ObjectivePrior studies have suggested that paternity may be associated with reduced prostate cancer (PCa) risk. Interpretation of these studies has been difficult given that none have considered potential confounding by other risk factors for PCa such as PSA screening, race, and family history of cancer. We sought to determine the independent association of fatherhood with PCa. Prior studies have suggested that paternity may be associated with reduced prostate cancer (PCa) risk. Interpretation of these studies has been difficult given that none have considered potential confounding by other risk factors for PCa such as PSA screening, race, and family history of cancer. We sought to determine the independent association of fatherhood with PCa. DesignPopulation-based case-control study. Population-based case-control study. Materials and methodsParticipants from two population-based case-control studies of PCa were studied. Incident cases of PCa in King County, WA were identified from the SEER cancer registry. Controls were frequency matched by age and identified by random digit dialing. Number of children fathered was determined by self-report. A history of clinical infertility was queried among a subset of study participants. PCa risk associated with fatherhood and infertility was assessed with multivariate logistic regression. Participants from two population-based case-control studies of PCa were studied. Incident cases of PCa in King County, WA were identified from the SEER cancer registry. Controls were frequency matched by age and identified by random digit dialing. Number of children fathered was determined by self-report. A history of clinical infertility was queried among a subset of study participants. PCa risk associated with fatherhood and infertility was assessed with multivariate logistic regression. ResultsData from 1,645 cases of PCa and 1,754 controls were analyzed. There was no substantial difference in the proportion of cases and controls who reported never fathering a child (12.9% and 14.3%, respectively, P=0.34). Age-adjusted analyses showed that compared to those with zero or one child, men who fathered two or more children had a non-significant 13% reduction in prostate cancer risk (adjusted OR 0.87, 95% CI 0.74-1.02; P=0.09). Men who reported a history of infertility had a non-significant increase in PCa risk relative to those who did not (adjusted OR 1.29, 95% CI 0.96 – 1.73; P=0.1). Further adjustment for PSA screening, family history of PCa, marital status and vasectomy status did not significantly change risk estimates. Data from 1,645 cases of PCa and 1,754 controls were analyzed. There was no substantial difference in the proportion of cases and controls who reported never fathering a child (12.9% and 14.3%, respectively, P=0.34). Age-adjusted analyses showed that compared to those with zero or one child, men who fathered two or more children had a non-significant 13% reduction in prostate cancer risk (adjusted OR 0.87, 95% CI 0.74-1.02; P=0.09). Men who reported a history of infertility had a non-significant increase in PCa risk relative to those who did not (adjusted OR 1.29, 95% CI 0.96 – 1.73; P=0.1). Further adjustment for PSA screening, family history of PCa, marital status and vasectomy status did not significantly change risk estimates. ConclusionFathering two or more children was associated with a modest reduction in the relative risk of PCa, while a history of clinical infertility was associated with an increased relative risk of PCa in this population-based study. Further study of the association between paternity, male infertility and subsequent risk of prostate cancer is warranted. Fathering two or more children was associated with a modest reduction in the relative risk of PCa, while a history of clinical infertility was associated with an increased relative risk of PCa in this population-based study. Further study of the association between paternity, male infertility and subsequent risk of prostate cancer is warranted." @default.
• W2084355655 created "2016-06-24" @default.
• W2084355655 creator A5054491363 @default.
• W2084355655 creator A5071800632 @default.
• W2084355655 creator A5080866168 @default.
• W2084355655 date "2012-09-01" @default.
• W2084355655 modified "2023-10-16" @default.
• W2084355655 title "Fatherhood and prostate cancer risk in a population-based case-control study" @default.
• W2084355655 doi "https://doi.org/10.1016/j.fertnstert.2012.07.546" @default.
• W2084355655 hasPublicationYear "2012" @default.
• W2084355655 type Work @default.
• W2084355655 sameAs 2084355655 @default.
• W2084355655 citedByCount "0" @default.
• W2084355655 crossrefType "journal-article" @default.
• W2084355655 hasAuthorship W2084355655A5054491363 @default.
• W2084355655 hasAuthorship W2084355655A5071800632 @default.
• W2084355655 hasAuthorship W2084355655A5080866168 @default.
• W2084355655 hasBestOaLocation W20843556551 @default.
• W2084355655 hasConcept C121608353 @default.
• W2084355655 hasConcept C126322002 @default.
• W2084355655 hasConcept C144024400 @default.
• W2084355655 hasConcept C146304588 @default.
• W2084355655 hasConcept C149923435 @default.
• W2084355655 hasConcept C151956035 @default.
• W2084355655 hasConcept C2777688143 @default.
• W2084355655 hasConcept C2778527826 @default.
• W2084355655 hasConcept C2779234561 @default.
• W2084355655 hasConcept C2780192828 @default.
• W2084355655 hasConcept C2781179581 @default.
• W2084355655 hasConcept C2908647359 @default.
• W2084355655 hasConcept C29456083 @default.
• W2084355655 hasConcept C54355233 @default.
• W2084355655 hasConcept C60034152 @default.
• W2084355655 hasConcept C71924100 @default.
• W2084355655 hasConcept C77350462 @default.
• W2084355655 hasConcept C86803240 @default.
• W2084355655 hasConcept C99454951 @default.
• W2084355655 hasConceptScore W2084355655C121608353 @default.
• W2084355655 hasConceptScore W2084355655C126322002 @default.
• W2084355655 hasConceptScore W2084355655C144024400 @default.
• W2084355655 hasConceptScore W2084355655C146304588 @default.
• W2084355655 hasConceptScore W2084355655C149923435 @default.
• W2084355655 hasConceptScore W2084355655C151956035 @default.
• W2084355655 hasConceptScore W2084355655C2777688143 @default.
• W2084355655 hasConceptScore W2084355655C2778527826 @default.
• W2084355655 hasConceptScore W2084355655C2779234561 @default.
• W2084355655 hasConceptScore W2084355655C2780192828 @default.
• W2084355655 hasConceptScore W2084355655C2781179581 @default.
• W2084355655 hasConceptScore W2084355655C2908647359 @default.
• W2084355655 hasConceptScore W2084355655C29456083 @default.
• W2084355655 hasConceptScore W2084355655C54355233 @default.
• W2084355655 hasConceptScore W2084355655C60034152 @default.
• W2084355655 hasConceptScore W2084355655C71924100 @default.
• W2084355655 hasConceptScore W2084355655C77350462 @default.
• W2084355655 hasConceptScore W2084355655C86803240 @default.
• W2084355655 hasConceptScore W2084355655C99454951 @default.
• W2084355655 hasIssue "3" @default.
• W2084355655 hasLocation W20843556551 @default.
• W2084355655 hasOpenAccess W2084355655 @default.
• W2084355655 hasPrimaryLocation W20843556551 @default.
• W2084355655 hasRelatedWork W2016699966 @default.
• W2084355655 hasRelatedWork W2079332344 @default.
• W2084355655 hasRelatedWork W2129757393 @default.
• W2084355655 hasRelatedWork W2193827770 @default.
• W2084355655 hasRelatedWork W2406718990 @default.
• W2084355655 hasRelatedWork W2408496128 @default.
• W2084355655 hasRelatedWork W2472236813 @default.
• W2084355655 hasRelatedWork W2519069507 @default.
• W2084355655 hasRelatedWork W2591870772 @default.
• W2084355655 hasRelatedWork W3204927694 @default.
• W2084355655 hasVolume "98" @default.
• W2084355655 isParatext "false" @default.
• W2084355655 isRetracted "false" @default.
• W2084355655 magId "2084355655" @default.
• W2084355655 workType "article" @default.