FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084362641> ?p ?o ?g. }

• W2084362641 endingPage "555" @default.
• W2084362641 startingPage "547" @default.
• W2084362641 abstract "Although tobacco is the major lung cancer risk factor, folate deficiency has also been implicated as a risk. Methionine synthase (MS; gene symbol, MTR) and methionine synthase reductase (MSR; gene symbol, MTRR) play important roles in the folate metabolism pathway. It was hypothesized that polymorphisms of MTR and MTRR are associated with lung cancer risk and interact with dietary intake of folate-related nutrients in lung cancer etiology. In a hospital-based, case–control study of 1035 lung cancer cases and 1148 controls of non-Hispanic whites, frequency matched by age, sex, ethnicity and smoking status, the MTR 2756A>G and MTRR 66A>G polymorphisms were genotyped. It was found that the MTRRG allele was associated with a significantly increased lung cancer risk [adjusted odd ratio (OR)=1.34, 95% confidence interval (CI)=1.06–1.70 for the AG genotype and OR=1.39, 95% CI=1.08–1.78 for the GG genotype compared to the AA genotype]. Further analysis suggested some evidence of gene–diet interactions between the MTRR 66A>G polymorphism and dietary intake of total folate and vitamin B12. When the two polymorphisms were evaluated together by the number of the variant alleles (i.e. the MTR2756G and MTRR66A), lung cancer risk was significantly increased in a dose-dependent manner (Ptrend=0.045). The risk of lung cancer was 1.29 (0.98–1.69) for one variant allele, and 1.36 (1.04–1.77) for two or more variant alleles compared to the wild-type (0 variant allele) genotype. In conclusion, our data provide evidence supporting the association between the MTR 2756A>G and MTRR 66A>G polymorphisms and lung cancer risk, which may be modulated by dietary nutrient intake." @default.
• W2084362641 created "2016-06-24" @default.
• W2084362641 creator A5006617799 @default.
• W2084362641 creator A5012002845 @default.
• W2084362641 creator A5024324856 @default.
• W2084362641 creator A5047095924 @default.
• W2084362641 creator A5047291076 @default.
• W2084362641 creator A5060545230 @default.
• W2084362641 creator A5068341243 @default.
• W2084362641 date "2005-08-01" @default.
• W2084362641 modified "2023-10-14" @default.
• W2084362641 title "Polymorphisms of methionine synthase and methionine synthase reductase and risk of lung cancer: a case–control analysis" @default.
• W2084362641 cites W1507471893 @default.
• W2084362641 cites W1525040400 @default.
• W2084362641 cites W1566350301 @default.
• W2084362641 cites W1572140777 @default.
• W2084362641 cites W1572305422 @default.
• W2084362641 cites W1622309784 @default.
• W2084362641 cites W1782392064 @default.
• W2084362641 cites W1964794938 @default.
• W2084362641 cites W1975994684 @default.
• W2084362641 cites W1976312565 @default.
• W2084362641 cites W1978438234 @default.
• W2084362641 cites W1983419413 @default.
• W2084362641 cites W1983475623 @default.
• W2084362641 cites W1986795920 @default.
• W2084362641 cites W1989800882 @default.
• W2084362641 cites W1989823445 @default.
• W2084362641 cites W1996010884 @default.
• W2084362641 cites W1997797062 @default.
• W2084362641 cites W2001525363 @default.
• W2084362641 cites W2014831203 @default.
• W2084362641 cites W2017488615 @default.
• W2084362641 cites W2023272768 @default.
• W2084362641 cites W2024558578 @default.
• W2084362641 cites W2025755447 @default.
• W2084362641 cites W2044170424 @default.
• W2084362641 cites W2048731329 @default.
• W2084362641 cites W2057469776 @default.
• W2084362641 cites W2067691482 @default.
• W2084362641 cites W2077927747 @default.
• W2084362641 cites W2081532048 @default.
• W2084362641 cites W2091727242 @default.
• W2084362641 cites W2095068177 @default.
• W2084362641 cites W2098130011 @default.
• W2084362641 cites W2104575676 @default.
• W2084362641 cites W2106619928 @default.
• W2084362641 cites W2109307191 @default.
• W2084362641 cites W2111392737 @default.
• W2084362641 cites W2114702800 @default.
• W2084362641 cites W2124036673 @default.
• W2084362641 cites W2134495789 @default.
• W2084362641 cites W2135114425 @default.
• W2084362641 cites W2135684856 @default.
• W2084362641 cites W2136648615 @default.
• W2084362641 cites W2144500318 @default.
• W2084362641 cites W2148712648 @default.
• W2084362641 cites W2149588972 @default.
• W2084362641 cites W2160444453 @default.
• W2084362641 cites W2171062435 @default.
• W2084362641 cites W2184910961 @default.
• W2084362641 cites W2286998608 @default.
• W2084362641 cites W2295137274 @default.
• W2084362641 cites W2322295556 @default.
• W2084362641 cites W2337261073 @default.
• W2084362641 doi "https://doi.org/10.1097/01.fpc.0000170916.96650.70" @default.
• W2084362641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16006998" @default.
• W2084362641 hasPublicationYear "2005" @default.
• W2084362641 type Work @default.
• W2084362641 sameAs 2084362641 @default.
• W2084362641 citedByCount "46" @default.
• W2084362641 countsByYear W20843626412012 @default.
• W2084362641 countsByYear W20843626412013 @default.
• W2084362641 countsByYear W20843626412015 @default.
• W2084362641 countsByYear W20843626412016 @default.
• W2084362641 countsByYear W20843626412017 @default.
• W2084362641 countsByYear W20843626412019 @default.
• W2084362641 countsByYear W20843626412020 @default.
• W2084362641 countsByYear W20843626412021 @default.
• W2084362641 countsByYear W20843626412023 @default.
• W2084362641 crossrefType "journal-article" @default.
• W2084362641 hasAuthorship W2084362641A5006617799 @default.
• W2084362641 hasAuthorship W2084362641A5012002845 @default.
• W2084362641 hasAuthorship W2084362641A5024324856 @default.
• W2084362641 hasAuthorship W2084362641A5047095924 @default.
• W2084362641 hasAuthorship W2084362641A5047291076 @default.
• W2084362641 hasAuthorship W2084362641A5060545230 @default.
• W2084362641 hasAuthorship W2084362641A5068341243 @default.
• W2084362641 hasConcept C104317684 @default.
• W2084362641 hasConcept C126322002 @default.
• W2084362641 hasConcept C134018914 @default.
• W2084362641 hasConcept C135763542 @default.
• W2084362641 hasConcept C180754005 @default.
• W2084362641 hasConcept C2776256026 @default.
• W2084362641 hasConcept C2778087339 @default.
• W2084362641 hasConcept C2780912031 @default.
• W2084362641 hasConcept C37463918 @default.
• W2084362641 hasConcept C43563269 @default.

• next