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• W2084372096 abstract "1 The ionic mechanism of membrane hyperpolarization induced by adrenaline in rat diaphragm muscle fibres was studied. 2 Removal of the extracellular K+ ([K+]o) from Krebs-Ringer solution initially increased the resting membrane potential and then caused an increase in the intracellular Na+ activity ([Na+]i) and a decrease in the intracellular K+ activity ([K+]i). All the changes were maintained for more than 3 h. 3 Application of ouabain (0.1 mm) or lowering the temperature rapidly reduced the resting potential by about 10 mV in the K+-free solution. It then produced further progressive decreases in resting potential and in [K+]i and a progressive increase in [Na+]i. These observations indicate that an electrogenic Na-pump operates in the K+-free solution. 4 Removal of most of the Cl− in the K+-free solution did not affect the resting potential or the magnitude of the initial decrease produced by ouabain, despite an increased input resistance; this result implies a passive distribution of Cl−. 5 Adrenaline (30–60 μm) either added to the bathing solution or applied to the membrane by ionophoresis produced a hyperpolarization (3–10 mV: adrenaline hyperpolarization), the amplitude of which was decreased with a rise in [K+]o and increased with a reduction in [K+]o, but unaffected by the removal of Cl−. 6 Adrenaline produced an increase in input resistance, the relative magnitude (17–18%) of which was constant whether external K+ or Cl− was removed. In contrast, a conditioning membrane hyperpolarization hardly affected the resistance. 7 Ouabain (0.1 mm) or low temperature (8–10°C) abolished both the hyperpolarization and the increased input resistance induced by adrenaline. 8 The [K+]i, [Na+]i and the peak of the action potential remained unchanged after a 20 min exposure to adrenaline (30 μm). 9 The hyperpolarization induced by the replacement of all Na+ with Tris (Tris-hyperpolarization) in the K+-free solution was depressed by 39% during the early period (4–31 min) of exposure to adrenaline (30 μm), while it was enhanced by 26% during the later period (80–130 min). The initial depression suggested a decrease in the ratio of the membrane permeability for Na+ (PNa) to that for K+ (PK). 10 These results suggest that the adrenaline hyperpolarization is generated largely by a decrease in PNa/PK, which is associated with the activity of the Na-pump." @default.
• W2084372096 created "2016-06-24" @default.
• W2084372096 creator A5048088286 @default.
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• W2084372096 date "1987-07-01" @default.
• W2084372096 modified "2023-09-26" @default.
• W2084372096 title "Role of ion conductance changes and of the sodium-pump in adrenaline-induced hyperpolarization of rat diaphragm muscle fibres" @default.
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• W2084372096 doi "https://doi.org/10.1111/j.1476-5381.1987.tb11261.x" @default.
• W2084372096 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1853544" @default.
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