Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084373485> ?p ?o ?g. }
- W2084373485 endingPage "666" @default.
- W2084373485 startingPage "659" @default.
- W2084373485 abstract "We studied the effects of GH administration on myocardial structure and function in 20 patients with hypopituitarism (14 males and 6 females; mean +/- SE age, 47.2 +/- 2.6 yr; range, 31-59 yr) developed in adulthood because of pituitary or parapituitary tumors. All patients had GH deficiency (GHD), as assessed by a GH response of less than 4 micrograms/L to a standard insulin tolerance test (0.05 U kg, iv) and the combined pyridostigmine (120 mg, orally, at -60 min) plus GHRH (1 microgram/kg, iv, at 0 min) test. Patients received either placebo (n = 10) or GH substitution therapy (n = 10; 0.05 U/kg.day GH for 1 yr; 0.03 U/kg.day during the first month). M- and B-mode echocardiography and pulsed Doppler examination of transmitral flow were performed before treatment, 6 months and 1 yr after starting GH or placebo administration, and 15 days and 3 months after GH or placebo withdrawal. Twenty healthy subjects, matched for age, sex, body mass index, and physical activity, served as controls. Left ventricular dimensions, mass, and systolic function were normal in patients with adult-onset GHD; however, diastolic function, specifically E wave deceleration time, was altered. GH administration markedly increased left ventricular performance and reversed diastolic abnormalities at 6 and even more so at 12 months. On the other hand, a clear increase in left ventricular mass was seen after 12, but not after 6, months of GH administration (P < 0.01 vs. pretreatment values). In addition, although all changes induced by GH treatment disappeared within 3 months after GH withdrawal, at that time the increase in left ventricular mass was still detectable (P < 0.05 vs. pretreatment values). These data indicate that augmented left ventricular contractility is not strictly related to cardiac muscle growth, supporting the hypothesis that GH treatment increases the inotropic activity of myocardial fibers. In conclusion, GH treatment enhances cardiac function, increases cardiac mass, and reverses diastolic abnormalities in adults with hypopituitarism and GHD. However, long term studies are required to demonstrate that GH replacement therapy reduces cardiac death rate in these patients." @default.
- W2084373485 created "2016-06-24" @default.
- W2084373485 creator A5047594113 @default.
- W2084373485 creator A5050480076 @default.
- W2084373485 creator A5066513811 @default.
- W2084373485 creator A5072339850 @default.
- W2084373485 creator A5077893664 @default.
- W2084373485 creator A5086966384 @default.
- W2084373485 date "1995-02-01" @default.
- W2084373485 modified "2023-10-18" @default.
- W2084373485 title "Cardiac performance and mass in adults with hypopituitarism: effects of one year of growth hormone treatment." @default.
- W2084373485 cites W1604288949 @default.
- W2084373485 cites W1971751212 @default.
- W2084373485 cites W1979022842 @default.
- W2084373485 cites W1992055809 @default.
- W2084373485 cites W1995934832 @default.
- W2084373485 cites W2026782802 @default.
- W2084373485 cites W2027555503 @default.
- W2084373485 cites W2029599650 @default.
- W2084373485 cites W2033292054 @default.
- W2084373485 cites W2047024906 @default.
- W2084373485 cites W2056170470 @default.
- W2084373485 cites W2056415845 @default.
- W2084373485 cites W2057186901 @default.
- W2084373485 cites W2071082827 @default.
- W2084373485 cites W2081590661 @default.
- W2084373485 cites W2084760902 @default.
- W2084373485 cites W2120108803 @default.
- W2084373485 cites W2161622680 @default.
- W2084373485 cites W2296419927 @default.
- W2084373485 cites W2463006674 @default.
- W2084373485 cites W2316716187 @default.
- W2084373485 doi "https://doi.org/10.1210/jcem.80.2.7852533" @default.
- W2084373485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7852533" @default.
- W2084373485 hasPublicationYear "1995" @default.
- W2084373485 type Work @default.
- W2084373485 sameAs 2084373485 @default.
- W2084373485 citedByCount "60" @default.
- W2084373485 countsByYear W20843734852012 @default.
- W2084373485 countsByYear W20843734852014 @default.
- W2084373485 countsByYear W20843734852015 @default.
- W2084373485 countsByYear W20843734852016 @default.
- W2084373485 countsByYear W20843734852017 @default.
- W2084373485 countsByYear W20843734852019 @default.
- W2084373485 countsByYear W20843734852020 @default.
- W2084373485 countsByYear W20843734852022 @default.
- W2084373485 crossrefType "journal-article" @default.
- W2084373485 hasAuthorship W2084373485A5047594113 @default.
- W2084373485 hasAuthorship W2084373485A5050480076 @default.
- W2084373485 hasAuthorship W2084373485A5066513811 @default.
- W2084373485 hasAuthorship W2084373485A5072339850 @default.
- W2084373485 hasAuthorship W2084373485A5077893664 @default.
- W2084373485 hasAuthorship W2084373485A5086966384 @default.
- W2084373485 hasConcept C126322002 @default.
- W2084373485 hasConcept C134018914 @default.
- W2084373485 hasConcept C142724271 @default.
- W2084373485 hasConcept C204787440 @default.
- W2084373485 hasConcept C27081682 @default.
- W2084373485 hasConcept C2777391703 @default.
- W2084373485 hasConcept C2778491484 @default.
- W2084373485 hasConcept C2779113265 @default.
- W2084373485 hasConcept C2780221984 @default.
- W2084373485 hasConcept C2780346441 @default.
- W2084373485 hasConcept C3017594256 @default.
- W2084373485 hasConcept C511355011 @default.
- W2084373485 hasConcept C57900726 @default.
- W2084373485 hasConcept C71924100 @default.
- W2084373485 hasConcept C84393581 @default.
- W2084373485 hasConceptScore W2084373485C126322002 @default.
- W2084373485 hasConceptScore W2084373485C134018914 @default.
- W2084373485 hasConceptScore W2084373485C142724271 @default.
- W2084373485 hasConceptScore W2084373485C204787440 @default.
- W2084373485 hasConceptScore W2084373485C27081682 @default.
- W2084373485 hasConceptScore W2084373485C2777391703 @default.
- W2084373485 hasConceptScore W2084373485C2778491484 @default.
- W2084373485 hasConceptScore W2084373485C2779113265 @default.
- W2084373485 hasConceptScore W2084373485C2780221984 @default.
- W2084373485 hasConceptScore W2084373485C2780346441 @default.
- W2084373485 hasConceptScore W2084373485C3017594256 @default.
- W2084373485 hasConceptScore W2084373485C511355011 @default.
- W2084373485 hasConceptScore W2084373485C57900726 @default.
- W2084373485 hasConceptScore W2084373485C71924100 @default.
- W2084373485 hasConceptScore W2084373485C84393581 @default.
- W2084373485 hasIssue "2" @default.
- W2084373485 hasLocation W20843734851 @default.
- W2084373485 hasLocation W20843734852 @default.
- W2084373485 hasOpenAccess W2084373485 @default.
- W2084373485 hasPrimaryLocation W20843734851 @default.
- W2084373485 hasRelatedWork W1966234050 @default.
- W2084373485 hasRelatedWork W2005007743 @default.
- W2084373485 hasRelatedWork W2051917626 @default.
- W2084373485 hasRelatedWork W2052457305 @default.
- W2084373485 hasRelatedWork W2070194496 @default.
- W2084373485 hasRelatedWork W2078303268 @default.
- W2084373485 hasRelatedWork W2084373485 @default.
- W2084373485 hasRelatedWork W2142797342 @default.
- W2084373485 hasRelatedWork W2143249903 @default.
- W2084373485 hasRelatedWork W2171089442 @default.