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• W2084378412 startingPage "649" @default.
• W2084378412 abstract "Induction of tolerance to transplantation antigens is believed to be a promising way to achieve long-term allograft survival without a deleterious immunosuppressive regimen. T-cell activation, which is an essential feature of graft rejection, requires a first signal provided by T-cell receptor (TCR) ligation and a second signal provided by engagement of co-stimulatory molecules with their respective ligands on antigen-presenting cells. The coordinated triggering of these two independent signalling systems ensures the full T-cell activation, including proliferation and acquisition of effector function. TCR occupancy in the absence of co-stimulatory signals leads to a sustained loss of antigen responsiveness called clonal anergy, which could be of major importance in transplantation. In vivo, co-stimulation blockade was indeed shown to allow for long-term allograft survival in several transplantation models. However, the current continuous identification of new co-stimulatory molecules suggests that a functional redundancy of the system exists and that tolerance to transplantation antigens might be achieved more easily through the combined blockade of two or several co-stimulatory signals. In this review, we analyse the biological effects of the disruption of some co-stimulation pathways in vitro and in vivo and discuss their potential interest for tolerance induction." @default.
• W2084378412 created "2016-06-24" @default.
• W2084378412 creator A5006521056 @default.
• W2084378412 creator A5065766935 @default.
• W2084378412 creator A5080154745 @default.
• W2084378412 date "2001-05-29" @default.
• W2084378412 modified "2023-09-26" @default.
• W2084378412 title "Mechanisms of tolerance induction: blockade of co–stimulation" @default.
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• W2084378412 doi "https://doi.org/10.1098/rstb.2001.0842" @default.
• W2084378412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1088452" @default.
• W2084378412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11375068" @default.
• W2084378412 hasPublicationYear "2001" @default.
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