FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084386047> ?p ?o ?g. }

• W2084386047 endingPage "124" @default.
• W2084386047 startingPage "117" @default.
• W2084386047 abstract "Tri-n-butyltin (TBT) has long been considered as the most toxic among organotins, especially to membrane systems. The partially dealkylated derivative di-n-butyltin (DBT) has up to now received poor attention and, whenever considered, shown to be less toxic than TBT except on the immune system. The present kinetic approach evidences that both TBT and DBT in vitro inhibit the Mg-ATPase in mussel digestive gland mitochondria by a different mechanism. DBT even displays a higher efficiency than TBT (IC(50)=0.32 μM for TBT vs. 0.19 μM for DBT) in inhibiting the enzyme hydrolytic activity. Differently from TBT which at high concentrations (>1 μM) apparently decreases the oligomycin-sensitivity of the Mg-ATPase, DBT at any concentration tested does not affect the oligomycin sensitivity. TBT probably binds to F(0), either in the form of free enzyme or of enzyme-substrate complex (Ki=K'i), acting as non-competitive inhibitor with respect to the ATP substrate. Conversely DBT, which acts as uncompetitive inhibitor of ATP and as competitive inhibitor of Mg(2+) cofactor, may bind strongly to F(1) subunit, thus preventing ATP hydrolysis. The Mg-ATPase inhibition by both organotins warns against a potential threat to crucial cell energy metabolism processes even after years from contamination and partial TBT debutylation." @default.
• W2084386047 created "2016-06-24" @default.
• W2084386047 creator A5004405093 @default.
• W2084386047 creator A5034884753 @default.
• W2084386047 creator A5035815879 @default.
• W2084386047 creator A5071471020 @default.
• W2084386047 creator A5080305312 @default.
• W2084386047 creator A5089004786 @default.
• W2084386047 date "2011-02-01" @default.
• W2084386047 modified "2023-10-06" @default.
• W2084386047 title "Tributyltin (TBT) and dibutyltin (DBT) differently inhibit the mitochondrial Mg-ATPase activity in mussel digestive gland" @default.
• W2084386047 cites W1493930141 @default.
• W2084386047 cites W1964920524 @default.
• W2084386047 cites W1964976203 @default.
• W2084386047 cites W1970650317 @default.
• W2084386047 cites W1971926164 @default.
• W2084386047 cites W1993049173 @default.
• W2084386047 cites W1993625649 @default.
• W2084386047 cites W1994377128 @default.
• W2084386047 cites W1997919343 @default.
• W2084386047 cites W1998682580 @default.
• W2084386047 cites W2009941345 @default.
• W2084386047 cites W2010673622 @default.
• W2084386047 cites W2016475088 @default.
• W2084386047 cites W2021012427 @default.
• W2084386047 cites W2030745219 @default.
• W2084386047 cites W2033397022 @default.
• W2084386047 cites W2040441208 @default.
• W2084386047 cites W2057131312 @default.
• W2084386047 cites W2057420582 @default.
• W2084386047 cites W2061451325 @default.
• W2084386047 cites W2075332282 @default.
• W2084386047 cites W2078442772 @default.
• W2084386047 cites W2101123856 @default.
• W2084386047 cites W2101893734 @default.
• W2084386047 cites W2114208481 @default.
• W2084386047 cites W2124412111 @default.
• W2084386047 cites W2127026337 @default.
• W2084386047 cites W2127319992 @default.
• W2084386047 cites W2139883678 @default.
• W2084386047 cites W2153435210 @default.
• W2084386047 cites W2157740357 @default.
• W2084386047 cites W2162959890 @default.
• W2084386047 cites W2336783295 @default.
• W2084386047 cites W2337551426 @default.
• W2084386047 cites W2340940993 @default.
• W2084386047 cites W4293247451 @default.
• W2084386047 doi "https://doi.org/10.1016/j.tiv.2010.10.001" @default.
• W2084386047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20950683" @default.
• W2084386047 hasPublicationYear "2011" @default.
• W2084386047 type Work @default.
• W2084386047 sameAs 2084386047 @default.
• W2084386047 citedByCount "34" @default.
• W2084386047 countsByYear W20843860472012 @default.
• W2084386047 countsByYear W20843860472013 @default.
• W2084386047 countsByYear W20843860472014 @default.
• W2084386047 countsByYear W20843860472015 @default.
• W2084386047 countsByYear W20843860472016 @default.
• W2084386047 countsByYear W20843860472017 @default.
• W2084386047 countsByYear W20843860472018 @default.
• W2084386047 countsByYear W20843860472019 @default.
• W2084386047 countsByYear W20843860472020 @default.
• W2084386047 countsByYear W20843860472021 @default.
• W2084386047 countsByYear W20843860472022 @default.
• W2084386047 countsByYear W20843860472023 @default.
• W2084386047 crossrefType "journal-article" @default.
• W2084386047 hasAuthorship W2084386047A5004405093 @default.
• W2084386047 hasAuthorship W2084386047A5034884753 @default.
• W2084386047 hasAuthorship W2084386047A5035815879 @default.
• W2084386047 hasAuthorship W2084386047A5071471020 @default.
• W2084386047 hasAuthorship W2084386047A5080305312 @default.
• W2084386047 hasAuthorship W2084386047A5089004786 @default.
• W2084386047 hasConcept C107872376 @default.
• W2084386047 hasConcept C141315368 @default.
• W2084386047 hasConcept C150757390 @default.
• W2084386047 hasConcept C181199279 @default.
• W2084386047 hasConcept C185592680 @default.
• W2084386047 hasConcept C18903297 @default.
• W2084386047 hasConcept C23265538 @default.
• W2084386047 hasConcept C2777289219 @default.
• W2084386047 hasConcept C2779078112 @default.
• W2084386047 hasConcept C2779134199 @default.
• W2084386047 hasConcept C55493867 @default.
• W2084386047 hasConcept C86803240 @default.
• W2084386047 hasConceptScore W2084386047C107872376 @default.
• W2084386047 hasConceptScore W2084386047C141315368 @default.
• W2084386047 hasConceptScore W2084386047C150757390 @default.
• W2084386047 hasConceptScore W2084386047C181199279 @default.
• W2084386047 hasConceptScore W2084386047C185592680 @default.
• W2084386047 hasConceptScore W2084386047C18903297 @default.
• W2084386047 hasConceptScore W2084386047C23265538 @default.
• W2084386047 hasConceptScore W2084386047C2777289219 @default.
• W2084386047 hasConceptScore W2084386047C2779078112 @default.
• W2084386047 hasConceptScore W2084386047C2779134199 @default.
• W2084386047 hasConceptScore W2084386047C55493867 @default.
• W2084386047 hasConceptScore W2084386047C86803240 @default.
• W2084386047 hasIssue "1" @default.
• W2084386047 hasLocation W20843860471 @default.

• next