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- W2084388059 abstract "The effect of in vivo injections of human luteinizing hormone (hLH), human follicle stimulating hormone (hFSH) and ethanol on gonadotropin receptor sites in rat testes was studied. We found that hLH (32 IU) and hFSH (30 IU) reduced the number of their respective binding sites shortly after administration. The hLH was more rapid and effective in its action than hFSH. Hormone specificity was also evident in the depletion process. The hLH could not effectively deplete testicular hFSH receptors during the first 3 days and vice versa. Prolonged administration of ethanol (5 ml of 20% v/v ethanol in saline/injection; 2 injections/ day for 7 days) also led to depletion of gonadotropin receptor sites in rat testes but without the specificity displayed by hLH and hFSH. The receptor replenishment process commenced when ethanol was withdrawn and was essentially complete by Day 20 (or 13 days after ethanol withdrawal). The ability of ethanol to reduce gonadotropin binding through receptor depletion may be a possible cause of testicular atrophy, reduced steroidogenesis and impotency, problems frequently encountered in chronic alcoholics." @default.
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- W2084388059 date "1979-06-01" @default.
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- W2084388059 title "Receptor Depletion and Replenishment Processes: In vivo Regulation of Gonadotropin Receptors by Luteinizing Hormone, Follicle Stimulating Hormone and Ethanol in Rat Testis" @default.
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- W2084388059 doi "https://doi.org/10.1095/biolreprod20.5.991" @default.
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