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• W2084389584 abstract "SMAP2 is an Arf GTPase-activating protein that is located and functions on early endosome membranes. In the present study, the trans-Golgi network (TGN) was verified as an additional site of SMAP2 localization based on its co-localization with various TGN-marker proteins. Mutation of specific stretches of basic amino acid residues abolished the TGN-localization of SMAP2. Over-expression of wild-type SMAP2, but not of the mutated SMAP2, inhibited the transport of vesicular stomatitis virus-G protein from the TGN to the plasma membrane. In contrast, this transport was enhanced in SMAP2 (–/–) cells characterized by increased levels of the activated form of Arf. SMAP2 therefore belongs to an ArfGAP subtype that resides on the TGN and functions as a negative regulator of vesicle budding from the organelle." @default.
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• W2084389584 date "2011-01-01" @default.
• W2084389584 modified "2023-10-18" @default.
• W2084389584 title "Localization of SMAP2 to the TGN and its Function in the Regulation of TGN Protein Transport" @default.
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• W2084389584 doi "https://doi.org/10.1247/csf.10022" @default.
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