Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084394090> ?p ?o ?g. }
- W2084394090 endingPage "609" @default.
- W2084394090 startingPage "601" @default.
- W2084394090 abstract "Some coxsackievirus B serotypes are potentially diabetogenic. Previous studies revealed that the virulence and the tissue damage varied with the genetics of the virus strain as well as with the genetics of the mice. A single amino acid variation can alter virulence and tropism in both murine and in vitro models. However, the genetic determinants of this phenomenon have not been determined. In this study, infections with a laboratory strain of coxsackievirus B4 resulted in a diabetes-like syndrome in ICR mice, characterized by chronic pancreatic inflammation together with dysregulation in glucose metabolism, loss of pancreatic acinar tissue and persistent infection in islets. To characterize the genetic determinants involved in the mouse pancreas adaptation, the laboratory strain of coxsackievirus B4 was cloned for molecular characterization. Comparing the whole genome sequence of this virus strain with the other coxsackievirus B4 strains revealed some differences. Altogether 15 nucleotides were changed, resulting in 10 amino acid substitutions, which might be responsible for the pathogenic phenotype of this strain in mice. Anat Rec, 291:601–609, 2008. © 2008 Wiley-Liss, Inc." @default.
- W2084394090 created "2016-06-24" @default.
- W2084394090 creator A5018593334 @default.
- W2084394090 creator A5034579880 @default.
- W2084394090 date "2008-01-01" @default.
- W2084394090 modified "2023-10-16" @default.
- W2084394090 title "Complete Nucleotide Sequence of a Coxsackievirus B4 Strain that Establishes Infection in ICR Mice Pancreas and Induces Glucose Intolerance" @default.
- W2084394090 cites W1487649776 @default.
- W2084394090 cites W1593111486 @default.
- W2084394090 cites W1775817416 @default.
- W2084394090 cites W1941711607 @default.
- W2084394090 cites W1967588703 @default.
- W2084394090 cites W1974625287 @default.
- W2084394090 cites W1989052428 @default.
- W2084394090 cites W1989765696 @default.
- W2084394090 cites W1995016572 @default.
- W2084394090 cites W2001158961 @default.
- W2084394090 cites W2001295992 @default.
- W2084394090 cites W2008503024 @default.
- W2084394090 cites W2033867086 @default.
- W2084394090 cites W2037263220 @default.
- W2084394090 cites W2037774955 @default.
- W2084394090 cites W2041972900 @default.
- W2084394090 cites W2043204562 @default.
- W2084394090 cites W2044368373 @default.
- W2084394090 cites W2044543317 @default.
- W2084394090 cites W2051758487 @default.
- W2084394090 cites W2052152482 @default.
- W2084394090 cites W2060941186 @default.
- W2084394090 cites W2067146710 @default.
- W2084394090 cites W2069738932 @default.
- W2084394090 cites W2088350742 @default.
- W2084394090 cites W2090179268 @default.
- W2084394090 cites W2091219793 @default.
- W2084394090 cites W2094252744 @default.
- W2084394090 cites W2098175463 @default.
- W2084394090 cites W2106087071 @default.
- W2084394090 cites W2108545791 @default.
- W2084394090 cites W2118694116 @default.
- W2084394090 cites W2123150576 @default.
- W2084394090 cites W2138892620 @default.
- W2084394090 cites W2145833662 @default.
- W2084394090 cites W2152072371 @default.
- W2084394090 cites W2154100983 @default.
- W2084394090 cites W2156282850 @default.
- W2084394090 cites W2162477870 @default.
- W2084394090 cites W2163054986 @default.
- W2084394090 cites W2182464879 @default.
- W2084394090 cites W4240817237 @default.
- W2084394090 doi "https://doi.org/10.1002/ar.20690" @default.
- W2084394090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18384052" @default.
- W2084394090 hasPublicationYear "2008" @default.
- W2084394090 type Work @default.
- W2084394090 sameAs 2084394090 @default.
- W2084394090 citedByCount "1" @default.
- W2084394090 crossrefType "journal-article" @default.
- W2084394090 hasAuthorship W2084394090A5018593334 @default.
- W2084394090 hasAuthorship W2084394090A5034579880 @default.
- W2084394090 hasBestOaLocation W20843940901 @default.
- W2084394090 hasConcept C104317684 @default.
- W2084394090 hasConcept C105702510 @default.
- W2084394090 hasConcept C127716648 @default.
- W2084394090 hasConcept C134018914 @default.
- W2084394090 hasConcept C159047783 @default.
- W2084394090 hasConcept C165220095 @default.
- W2084394090 hasConcept C2522874641 @default.
- W2084394090 hasConcept C2777888124 @default.
- W2084394090 hasConcept C2778022156 @default.
- W2084394090 hasConcept C2779120600 @default.
- W2084394090 hasConcept C2779855799 @default.
- W2084394090 hasConcept C33602714 @default.
- W2084394090 hasConcept C35693153 @default.
- W2084394090 hasConcept C54355233 @default.
- W2084394090 hasConcept C555293320 @default.
- W2084394090 hasConcept C60987743 @default.
- W2084394090 hasConcept C86803240 @default.
- W2084394090 hasConcept C89423630 @default.
- W2084394090 hasConceptScore W2084394090C104317684 @default.
- W2084394090 hasConceptScore W2084394090C105702510 @default.
- W2084394090 hasConceptScore W2084394090C127716648 @default.
- W2084394090 hasConceptScore W2084394090C134018914 @default.
- W2084394090 hasConceptScore W2084394090C159047783 @default.
- W2084394090 hasConceptScore W2084394090C165220095 @default.
- W2084394090 hasConceptScore W2084394090C2522874641 @default.
- W2084394090 hasConceptScore W2084394090C2777888124 @default.
- W2084394090 hasConceptScore W2084394090C2778022156 @default.
- W2084394090 hasConceptScore W2084394090C2779120600 @default.
- W2084394090 hasConceptScore W2084394090C2779855799 @default.
- W2084394090 hasConceptScore W2084394090C33602714 @default.
- W2084394090 hasConceptScore W2084394090C35693153 @default.
- W2084394090 hasConceptScore W2084394090C54355233 @default.
- W2084394090 hasConceptScore W2084394090C555293320 @default.
- W2084394090 hasConceptScore W2084394090C60987743 @default.
- W2084394090 hasConceptScore W2084394090C86803240 @default.
- W2084394090 hasConceptScore W2084394090C89423630 @default.
- W2084394090 hasIssue "5" @default.
- W2084394090 hasLocation W20843940901 @default.
- W2084394090 hasLocation W20843940902 @default.