Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084407124> ?p ?o ?g. }
- W2084407124 endingPage "98" @default.
- W2084407124 startingPage "89" @default.
- W2084407124 abstract "Systemic administration of MK-801, an NMDA-receptor antagonist, impairs reversal learning in weanling rats [Chadman, K.K., Watson, D.J., & Stanton, M.E. (2006). NMDA-receptor antagonism impairs reversal learning in developing rats. Behavioral Neuroscience, 120(5), 1071–1083]. The brain systems responsible for this effect are not known in either adult or young animals. This study tested the hypothesis that hippocampal NMDA receptors are engaged in weanling-age rats during spatial discrimination reversal training in a T-maze. In Experiment 1, 26-day-old Long-Evans rats (P26) showed a dose-related impairment on this task following bilateral intrahippocampal administration of either 2.5 or 5.0 μg MK-801 or saline vehicle during the reversal training phase only. In Experiment 2, P26 rats were trained on the same task, but received intrahippocampal MK-801 (2.5 μg) during acquisition, reversal, both, or neither. MK-801 failed to impair acquisition, ruling out nonspecific “performance effects” of the drug. MK-801 impaired reversal irrespective of drug treatment during acquisition. NMDA-receptor antagonism in the hippocampus is sufficient to account for the previously reported effects of systemic MK-801 on reversal of T-maze position discrimination." @default.
- W2084407124 created "2016-06-24" @default.
- W2084407124 creator A5076962952 @default.
- W2084407124 creator A5077816873 @default.
- W2084407124 date "2009-07-01" @default.
- W2084407124 modified "2023-10-12" @default.
- W2084407124 title "Intrahippocampal administration of an NMDA-receptor antagonist impairs spatial discrimination reversal learning in weanling rats" @default.
- W2084407124 cites W1508276986 @default.
- W2084407124 cites W1589353809 @default.
- W2084407124 cites W1971553391 @default.
- W2084407124 cites W1978989737 @default.
- W2084407124 cites W1979694623 @default.
- W2084407124 cites W1981525906 @default.
- W2084407124 cites W1981753114 @default.
- W2084407124 cites W1982421314 @default.
- W2084407124 cites W1983062171 @default.
- W2084407124 cites W1983202833 @default.
- W2084407124 cites W1984005657 @default.
- W2084407124 cites W1984507853 @default.
- W2084407124 cites W1986822724 @default.
- W2084407124 cites W1988676936 @default.
- W2084407124 cites W1994202108 @default.
- W2084407124 cites W1994628686 @default.
- W2084407124 cites W1995056605 @default.
- W2084407124 cites W1995277843 @default.
- W2084407124 cites W2006139248 @default.
- W2084407124 cites W2011764575 @default.
- W2084407124 cites W2013636977 @default.
- W2084407124 cites W2016005609 @default.
- W2084407124 cites W2016332562 @default.
- W2084407124 cites W2025801062 @default.
- W2084407124 cites W2029172258 @default.
- W2084407124 cites W2034441621 @default.
- W2084407124 cites W2034648042 @default.
- W2084407124 cites W2036774393 @default.
- W2084407124 cites W2039508969 @default.
- W2084407124 cites W2048080687 @default.
- W2084407124 cites W2048260661 @default.
- W2084407124 cites W2049038171 @default.
- W2084407124 cites W2053521638 @default.
- W2084407124 cites W2065169750 @default.
- W2084407124 cites W2066279570 @default.
- W2084407124 cites W2067830356 @default.
- W2084407124 cites W2078210267 @default.
- W2084407124 cites W2078326510 @default.
- W2084407124 cites W2078879288 @default.
- W2084407124 cites W2079133060 @default.
- W2084407124 cites W2082046490 @default.
- W2084407124 cites W2086958280 @default.
- W2084407124 cites W2088987101 @default.
- W2084407124 cites W2089055897 @default.
- W2084407124 cites W2092687109 @default.
- W2084407124 cites W2098743881 @default.
- W2084407124 cites W2103214175 @default.
- W2084407124 cites W2103692957 @default.
- W2084407124 cites W2116635659 @default.
- W2084407124 cites W2119392695 @default.
- W2084407124 cites W2120481681 @default.
- W2084407124 cites W2136193713 @default.
- W2084407124 cites W2145465887 @default.
- W2084407124 cites W2145738949 @default.
- W2084407124 cites W2148714108 @default.
- W2084407124 cites W2150929574 @default.
- W2084407124 cites W2151511761 @default.
- W2084407124 cites W2157974426 @default.
- W2084407124 cites W2159323559 @default.
- W2084407124 cites W2163512640 @default.
- W2084407124 cites W2163815564 @default.
- W2084407124 cites W2165031188 @default.
- W2084407124 cites W2168844172 @default.
- W2084407124 cites W2477362681 @default.
- W2084407124 cites W587429664 @default.
- W2084407124 cites W644076287 @default.
- W2084407124 doi "https://doi.org/10.1016/j.nlm.2009.02.005" @default.
- W2084407124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2680934" @default.
- W2084407124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19248837" @default.
- W2084407124 hasPublicationYear "2009" @default.
- W2084407124 type Work @default.
- W2084407124 sameAs 2084407124 @default.
- W2084407124 citedByCount "42" @default.
- W2084407124 countsByYear W20844071242012 @default.
- W2084407124 countsByYear W20844071242013 @default.
- W2084407124 countsByYear W20844071242014 @default.
- W2084407124 countsByYear W20844071242015 @default.
- W2084407124 countsByYear W20844071242016 @default.
- W2084407124 countsByYear W20844071242017 @default.
- W2084407124 countsByYear W20844071242018 @default.
- W2084407124 countsByYear W20844071242019 @default.
- W2084407124 countsByYear W20844071242021 @default.
- W2084407124 countsByYear W20844071242023 @default.
- W2084407124 crossrefType "journal-article" @default.
- W2084407124 hasAuthorship W2084407124A5076962952 @default.
- W2084407124 hasAuthorship W2084407124A5077816873 @default.
- W2084407124 hasBestOaLocation W20844071242 @default.
- W2084407124 hasConcept C126322002 @default.
- W2084407124 hasConcept C148762608 @default.
- W2084407124 hasConcept C150903083 @default.
- W2084407124 hasConcept C15744967 @default.