FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084421843> ?p ?o ?g. }

• W2084421843 endingPage "R824" @default.
• W2084421843 startingPage "R815" @default.
• W2084421843 abstract "Neurons that synthesize melanin-concentrating hormone (MCH) colocalize GABA, regulate energy homeostasis, modulate water intake, and influence anxiety, stress, and social interaction. Similarly, vasopressin and oxytocin can influence the same behaviors and states, suggesting that these neuropeptides may exert part of their effect by modulating MCH neurons. Using whole cell recording in MCH-green fluorescent protein (GFP) transgenic mouse hypothalamic brain slices, we found that both vasopressin and oxytocin evoked a substantial excitatory effect. Both peptides reversibly increased spike frequency and depolarized the membrane potential in a concentration-dependent and tetrodotoxin-resistant manner, indicating a direct effect. Substitution of lithium for extracellular sodium, Na + /Ca 2+ exchanger blockers KB-R7943 and SN-6, and intracellular calcium chelator BAPTA, all substantially reduced the vasopressin-mediated depolarization, suggesting activation of the Na + /Ca 2+ exchanger. Vasopressin reduced input resistance, and the vasopressin-mediated depolarization was attenuated by SKF-96265, suggesting a second mechanism based on opening nonselective cation channels. Neither vasopressin nor oxytocin showed substantial excitatory actions on lateral hypothalamic inhibitory neurons identified in a glutamate decarboxylase 67 (GAD67)-GFP mouse. The primary vasopressin receptor was vasopressin receptor 1a (V1aR), as suggested by the excitation by V1aR agonist [Arg 8 ]vasotocin, the selective V1aR agonist [Phe 2 ]OVT and by the presence of V1aR mRNA in MCH cells, but not in other nearby GABA cells, as detected with single-cell RT-PCR. Oxytocin receptor mRNA was also detected in MCH neurons. Together, these data suggest that vasopressin or oxytocin exert a minimal effect on most GABA neurons in the lateral hypothalamus but exert a robust excitatory effect on presumptive GABA cells that contain MCH. Thus, some of the central actions of vasopressin and oxytocin may be mediated through MCH cells." @default.
• W2084421843 created "2016-06-24" @default.
• W2084421843 creator A5004172478 @default.
• W2084421843 creator A5017875130 @default.
• W2084421843 creator A5032745814 @default.
• W2084421843 creator A5058830819 @default.
• W2084421843 date "2012-04-01" @default.
• W2084421843 modified "2023-09-27" @default.
• W2084421843 title "Vasopressin and oxytocin excite MCH neurons, but not other lateral hypothalamic GABA neurons" @default.
• W2084421843 cites W1481893565 @default.
• W2084421843 cites W1523553171 @default.
• W2084421843 cites W1524178766 @default.
• W2084421843 cites W1586661908 @default.
• W2084421843 cites W1627229807 @default.
• W2084421843 cites W1806892368 @default.
• W2084421843 cites W1825581609 @default.
• W2084421843 cites W1838211711 @default.
• W2084421843 cites W1975731777 @default.
• W2084421843 cites W1978082185 @default.
• W2084421843 cites W1979093338 @default.
• W2084421843 cites W1979804663 @default.
• W2084421843 cites W1982672191 @default.
• W2084421843 cites W1990288663 @default.
• W2084421843 cites W1993137505 @default.
• W2084421843 cites W1996622763 @default.
• W2084421843 cites W1998872047 @default.
• W2084421843 cites W2012950586 @default.
• W2084421843 cites W2017208259 @default.
• W2084421843 cites W2019803946 @default.
• W2084421843 cites W2020446572 @default.
• W2084421843 cites W2021288418 @default.
• W2084421843 cites W2028649508 @default.
• W2084421843 cites W2029723664 @default.
• W2084421843 cites W2033166789 @default.
• W2084421843 cites W2034196891 @default.
• W2084421843 cites W2035547334 @default.
• W2084421843 cites W2035780360 @default.
• W2084421843 cites W2037668299 @default.
• W2084421843 cites W2037692685 @default.
• W2084421843 cites W2041088128 @default.
• W2084421843 cites W2047638952 @default.
• W2084421843 cites W2051573127 @default.
• W2084421843 cites W2052363965 @default.
• W2084421843 cites W2055772188 @default.
• W2084421843 cites W2058147277 @default.
• W2084421843 cites W2063020601 @default.
• W2084421843 cites W2066503167 @default.
• W2084421843 cites W2075690161 @default.
• W2084421843 cites W2077425962 @default.
• W2084421843 cites W2088844563 @default.
• W2084421843 cites W2096795369 @default.
• W2084421843 cites W2099808541 @default.
• W2084421843 cites W2101580202 @default.
• W2084421843 cites W2103409581 @default.
• W2084421843 cites W2104096322 @default.
• W2084421843 cites W2106158417 @default.
• W2084421843 cites W2115902692 @default.
• W2084421843 cites W2121147520 @default.
• W2084421843 cites W2138262820 @default.
• W2084421843 cites W2148141945 @default.
• W2084421843 cites W2149050611 @default.
• W2084421843 cites W2240825980 @default.
• W2084421843 cites W2284073410 @default.
• W2084421843 cites W4242549075 @default.
• W2084421843 cites W4252265800 @default.
• W2084421843 doi "https://doi.org/10.1152/ajpregu.00452.2011" @default.
• W2084421843 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3330772" @default.
• W2084421843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22262306" @default.
• W2084421843 hasPublicationYear "2012" @default.
• W2084421843 type Work @default.
• W2084421843 sameAs 2084421843 @default.
• W2084421843 citedByCount "24" @default.
• W2084421843 countsByYear W20844218432012 @default.
• W2084421843 countsByYear W20844218432013 @default.
• W2084421843 countsByYear W20844218432014 @default.
• W2084421843 countsByYear W20844218432016 @default.
• W2084421843 countsByYear W20844218432017 @default.
• W2084421843 countsByYear W20844218432018 @default.
• W2084421843 countsByYear W20844218432019 @default.
• W2084421843 countsByYear W20844218432020 @default.
• W2084421843 countsByYear W20844218432021 @default.
• W2084421843 countsByYear W20844218432022 @default.
• W2084421843 countsByYear W20844218432023 @default.
• W2084421843 crossrefType "journal-article" @default.
• W2084421843 hasAuthorship W2084421843A5004172478 @default.
• W2084421843 hasAuthorship W2084421843A5017875130 @default.
• W2084421843 hasAuthorship W2084421843A5032745814 @default.
• W2084421843 hasAuthorship W2084421843A5058830819 @default.
• W2084421843 hasBestOaLocation W20844218432 @default.
• W2084421843 hasConcept C118303440 @default.
• W2084421843 hasConcept C126322002 @default.
• W2084421843 hasConcept C134018914 @default.
• W2084421843 hasConcept C170493617 @default.
• W2084421843 hasConcept C181612422 @default.
• W2084421843 hasConcept C185592680 @default.
• W2084421843 hasConcept C2776176026 @default.
• W2084421843 hasConcept C2776370428 @default.
• W2084421843 hasConcept C2777003273 @default.

• next