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- W2084422016 abstract "Chinook salmon embryo cells have been infected with infectious hematopoietic necrosis virus (IHNV) to form virus-producing and nonproducing cell lines. In the producing persistently infected cells, high levels of virus were released into the medium. Yet, these cells continued to grow well in culture. Persistence is apparently mediated by several factors which include development of temperature-sensitive mutants, small plaque mutants, and defective interfering particles. Interferon did not play a significant role in the maintenance of virus persistence since these cells were susceptible to heterologous virus infection. This laboratory model of the virus-carrier state should be valuable in defining those factors which influence the outcome of IHNV infection of salmon." @default.
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- W2084422016 title "IHNV persistently infects chinook salmon embryo cells" @default.
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- W2084422016 doi "https://doi.org/10.1016/0042-6822(81)90470-0" @default.
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