Matches in SemOpenAlex for { <https://semopenalex.org/work/W2084433384> ?p ?o ?g. }
- W2084433384 endingPage "211" @default.
- W2084433384 startingPage "204" @default.
- W2084433384 abstract "Fourteen American Cocker Spaniels (ACS) with dilated cardiomyopathy (DCM) were studied to determine if individuals of this breed with DCM are systemically taurine‐or carnitine‐deficient and to determine if they are responsive to taurine and carnitine supplementation. American Cocker Spaniels with DCM were identified using echocardiography, and plasma was analyzed for taurine and carnitine concentrations. Each dog was randomly assigned to receive either taurine and carnitine supplementation or placebos. Echocardiograms and clinical examinations were repeated monthly for 4 months. During this period, the investigators and owners were blinded with respect to the treatment being administered. Each dog was weaned off its cardiovascular drugs (furosemide, digoxin, and an angiotensin converting enzyme inhibitor) if an echocardio‐graphic response was identified. At the 4‐month time period, each investigator was asked to decide whether he or she thought his or her patient was receiving placebo or taurine/ carnitine, based on presence or absence of clinical and echocar‐diographic improvement. Unblinding then occurred, and dogs receiving placebos were switched to taurine and carnitine supplementation and followed monthly for 4 additional months. All dogs were reexamined 6 months after starting supplementation; survival time and cause of death were recorded for each dog. Data from 3 dogs were not included because of multiple protocol violations. Each dog had a plasma taurine concentration <50 nmol/mL (mean ±SD for the group 15 ± 17 nmol/ mL) at baseline; normal range, 50–180 nmol/mL. The plasma taurine concentration did not exceed 50 nmol/mL at any time in the dogs receiving placebos (n = 5), but increased to 357 ± 157 nmol/mL (range 140–621 nmol/mL) during taurine and carnitine supplementation (n = 11). Plasma carnitine concentration was within, only slightly below, or slightly above reported limits of normality at baseline (29 ± 15 μmol/L); did not change during placebo administration; and increased significantly during supplementation (349 ±119 μmol/L; n = 11). Echocardiographic variables did not change during placebo administration. During supplementation, left ventricular end‐dia‐stolic and end‐systolic diameters, and mitral valve E point‐to‐septal separation decreased significantly in both groups. Shortening fraction increased significantly but not into the normal range. Echocardiographic variables remained improved at 6 months. All dogs were successfully weaned off furosemide, an angiotensin converting enzyme inhibitor, and digoxin once an echocardiographic response was identified. Nine of the dogs have died since the onset of the study in 1992. One dog died of recurrence of DCM and heart failure 31 months after starting supplementation; six dogs died of noncardiac causes. Two dogs developed degenerative mitral valve disease and died of complications of this disease. Dogs less than 10 years of age lived for 46 ± 11 months, whereas dogs older than 10 years of age lived for 14 ± 7 months. Two of the 11 dogs were alive at the time of publication, having survived for 3.5 and 4.5 years, respectively. We conclude that ACS with DCM are taurine‐deficient and are responsive to taurine and carnitine supplementation. Whereas myocardial function did not return to normal in most dogs, it did improve enough to allow discontinuation of cardiovascular drug therapy and to maintain a normal quality of life for months to years." @default.
- W2084433384 created "2016-06-24" @default.
- W2084433384 creator A5019866394 @default.
- W2084433384 creator A5030622169 @default.
- W2084433384 creator A5062471091 @default.
- W2084433384 creator A5071394873 @default.
- W2084433384 date "1997-07-01" @default.
- W2084433384 modified "2023-10-17" @default.
- W2084433384 title "Results of the Multicenter Spaniel Trial (MUST): Taurine‐and Carnitine‐Responsive Dilated Cardiomyopathy in American Cocker Spaniels With Decreased Plasma Taurine Concentration" @default.
- W2084433384 cites W141228391 @default.
- W2084433384 cites W1801774499 @default.
- W2084433384 cites W1965686308 @default.
- W2084433384 cites W2023640946 @default.
- W2084433384 cites W2057771709 @default.
- W2084433384 cites W2060091814 @default.
- W2084433384 cites W2105603989 @default.
- W2084433384 cites W2136879982 @default.
- W2084433384 cites W2442929904 @default.
- W2084433384 doi "https://doi.org/10.1111/j.1939-1676.1997.tb00092.x" @default.
- W2084433384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9298474" @default.
- W2084433384 hasPublicationYear "1997" @default.
- W2084433384 type Work @default.
- W2084433384 sameAs 2084433384 @default.
- W2084433384 citedByCount "130" @default.
- W2084433384 countsByYear W20844333842012 @default.
- W2084433384 countsByYear W20844333842013 @default.
- W2084433384 countsByYear W20844333842014 @default.
- W2084433384 countsByYear W20844333842015 @default.
- W2084433384 countsByYear W20844333842016 @default.
- W2084433384 countsByYear W20844333842017 @default.
- W2084433384 countsByYear W20844333842018 @default.
- W2084433384 countsByYear W20844333842019 @default.
- W2084433384 countsByYear W20844333842020 @default.
- W2084433384 countsByYear W20844333842021 @default.
- W2084433384 countsByYear W20844333842022 @default.
- W2084433384 countsByYear W20844333842023 @default.
- W2084433384 crossrefType "journal-article" @default.
- W2084433384 hasAuthorship W2084433384A5019866394 @default.
- W2084433384 hasAuthorship W2084433384A5030622169 @default.
- W2084433384 hasAuthorship W2084433384A5062471091 @default.
- W2084433384 hasAuthorship W2084433384A5071394873 @default.
- W2084433384 hasBestOaLocation W20844333841 @default.
- W2084433384 hasConcept C126322002 @default.
- W2084433384 hasConcept C134018914 @default.
- W2084433384 hasConcept C142724271 @default.
- W2084433384 hasConcept C164705383 @default.
- W2084433384 hasConcept C185592680 @default.
- W2084433384 hasConcept C204787440 @default.
- W2084433384 hasConcept C27081682 @default.
- W2084433384 hasConcept C2776383484 @default.
- W2084433384 hasConcept C2777955127 @default.
- W2084433384 hasConcept C2778198053 @default.
- W2084433384 hasConcept C2778435403 @default.
- W2084433384 hasConcept C2778797674 @default.
- W2084433384 hasConcept C2779701627 @default.
- W2084433384 hasConcept C42219234 @default.
- W2084433384 hasConcept C515207424 @default.
- W2084433384 hasConcept C55493867 @default.
- W2084433384 hasConcept C71924100 @default.
- W2084433384 hasConcept C90924648 @default.
- W2084433384 hasConceptScore W2084433384C126322002 @default.
- W2084433384 hasConceptScore W2084433384C134018914 @default.
- W2084433384 hasConceptScore W2084433384C142724271 @default.
- W2084433384 hasConceptScore W2084433384C164705383 @default.
- W2084433384 hasConceptScore W2084433384C185592680 @default.
- W2084433384 hasConceptScore W2084433384C204787440 @default.
- W2084433384 hasConceptScore W2084433384C27081682 @default.
- W2084433384 hasConceptScore W2084433384C2776383484 @default.
- W2084433384 hasConceptScore W2084433384C2777955127 @default.
- W2084433384 hasConceptScore W2084433384C2778198053 @default.
- W2084433384 hasConceptScore W2084433384C2778435403 @default.
- W2084433384 hasConceptScore W2084433384C2778797674 @default.
- W2084433384 hasConceptScore W2084433384C2779701627 @default.
- W2084433384 hasConceptScore W2084433384C42219234 @default.
- W2084433384 hasConceptScore W2084433384C515207424 @default.
- W2084433384 hasConceptScore W2084433384C55493867 @default.
- W2084433384 hasConceptScore W2084433384C71924100 @default.
- W2084433384 hasConceptScore W2084433384C90924648 @default.
- W2084433384 hasIssue "4" @default.
- W2084433384 hasLocation W20844333841 @default.
- W2084433384 hasLocation W20844333842 @default.
- W2084433384 hasLocation W20844333843 @default.
- W2084433384 hasOpenAccess W2084433384 @default.
- W2084433384 hasPrimaryLocation W20844333841 @default.
- W2084433384 hasRelatedWork W1996190273 @default.
- W2084433384 hasRelatedWork W2044992314 @default.
- W2084433384 hasRelatedWork W2065541362 @default.
- W2084433384 hasRelatedWork W2141412899 @default.
- W2084433384 hasRelatedWork W2319553557 @default.
- W2084433384 hasRelatedWork W2380633980 @default.
- W2084433384 hasRelatedWork W2429265210 @default.
- W2084433384 hasRelatedWork W2475216369 @default.
- W2084433384 hasRelatedWork W2947205928 @default.
- W2084433384 hasRelatedWork W6228773 @default.
- W2084433384 hasVolume "11" @default.
- W2084433384 isParatext "false" @default.
- W2084433384 isRetracted "false" @default.
- W2084433384 magId "2084433384" @default.