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• W2084443721 abstract "Abstract Multiple plasma peaks of acetaminophen (AAP) were observed following oral administration of an AAP (40 mg/kg) suspension to fasted rats. The multiple peaks were not diminished when the AAP suspension was administered to enterohepatic recycling-blocked (ERB) rats. Therefore, enterohepatic recycling does not contribute significantly to the multiple peaks of orally administered AAP in rats. After intravenous administration of AAP (40 mg/kg) solution to 10 rats, 10% of the rats showed distinct multiple plasma peaks. This indicates that multiple peaks may be unrelated to the gastrointestinal absorption process for some drugs." @default.
• W2084443721 created "2016-06-24" @default.
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• W2084443721 date "1992-06-01" @default.
• W2084443721 modified "2023-09-26" @default.
• W2084443721 title "Noncontribution of enterohepatic recycling to multiple plasma peaks of acetaminophen in rats" @default.
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• W2084443721 doi "https://doi.org/10.1016/0378-5173(82)90030-8" @default.
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