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- W2084445848 abstract "Objectives: This clinical study is planned to investigate felodipine based combination of the antihypertensive drugs, that is whether felodipine plus irbesartan or plus metoprolol is superior to achieve the targeted blood pressure and prevent cardiomegaly in patients with uncomplicated hypertension. Methods: Fifty-eight patients (aged 18 to 60) with grade 1 and grade 2 uncomplicated hypertension (BP ≥140/90 mm Hg and <179/109 mm Hg) were assigned randomly to felodipine (5 mg q.d.)+irbesartan (150 mg q.d., F+I group, n=28) group and felodipine (5 mg q.d.)+metoprolol (47.5 mg q.d., F+M group, n=30) group. Target blood pressure is <140/90 mm Hg. Transthoracic echocardiography evaluation was performed. Left ventricular end-systolic dimension and left ventricular end-diastolic dimension (LVEDs, LVEDd) were measured and left ventricular mass (LVM) interventricular septum thickness (IST) and relative wall thickness (RWT) were calculated. All patients signed consent form and followed up for 48 weeks. The protocol was approved by the Ethic Committee of The Second Hospital of Lanzhou University. Results: The blood pressure between 2 groups was similar at the 4th, 8th, 24th and 48th weeks respectively (P>0.05). The LVEDs and LVEDd were both smaller compared with baseline in F+I group and F+M group at 48th week follow-up (P<0.05). The LVM and IST were also lesser compared with baseline both in F+I group and F+M group at 48th week (P<0.05). The LVEDs and LVEDd were smaller in F+I group compared with those in F+M group at 48th week (P<0.05). The LVM and IST were lesser in F+I group compared with those in F+M group at 48th week (P<0.05). Conclusion: These results suggest that felodipine–irbesartan combination regimen is superior to prevent cardiac hypertrophy in uncomplicated hypertensive patients compared with felodipine+metoprolol regimen." @default.
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- W2084445848 date "2011-10-01" @default.
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- W2084445848 title "Calcium channel blocker-based combination regimen to prevent cardiac hypertrophy in patients with hypertension" @default.
- W2084445848 doi "https://doi.org/10.1016/j.ijcard.2011.08.514" @default.
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