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- W2084450609 abstract "We correlated clinical, biochemical, and morphologic findings in the lungs of 48 infants dying of either bronchopulmonary dysplasia (BPD) or hyaline membrane disease (HMD) to obtain a better idea of the disease process. The infants ranged from 24 weeks of gestation to 1½ postnatal years. The lungs of BPD and HMD infants had higher contents of DNA, alkali-soluble protein, hydroxyproline, and desmosine, as well as increased concentrations of DNA, hydroxyproline, and desmosine when compared with the lungs of 72 control infants. BPD was classified histologically into 4 groups: Group I was a phase of acute lung injury; Group II the proliferative phase; Group III the phase of early repair; and Group IV the phase of late repair. We saw a significant increase in hydroxyproline concentration in Groups II and III. The ratio of type VIII collagen decreased in BPD Groups II to IV. Desmosine was significantly higher only in Group III than in controls. When the pathological classification was related to biochemical and clinical features of BPD, the classification showed dependence on the number of days the infant survived postnatally and not on the gestational age of the infant. The number of days on assisted ventilation was a slightly better predictor of the disease classification than days on > 60% oxygen. A statistical model correctly predicted the pathologic classification 83% of the time. Pediatr Pulmonol. 1996; 22:215–229. © 1996 Wiley-Liss, Inc." @default.
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- W2084450609 date "1996-10-01" @default.
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- W2084450609 title "Biochemical, clinical, and morphologic studies on lungs of infants with bronchopulmonary dysplasia" @default.
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- W2084450609 doi "https://doi.org/10.1002/(sici)1099-0496(199610)22:4<215::aid-ppul1>3.0.co;2-l" @default.
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