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• W2084464265 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Nov 2001AUGMENTED STRETCH ACTIVATED ADENOSINE TRIPHOSPHATE RELEASE FROM BLADDER UROEPITHELIAL CELLS IN PATIENTS WITH INTERSTITIAL CYSTITIS YAN SUN, SUSAN KEAY, PATRICK G. De DEYNE, and TOBY C. CHAI YAN SUNYAN SUN More articles by this author , SUSAN KEAYSUSAN KEAY More articles by this author , PATRICK G. De DEYNEPATRICK G. De DEYNE More articles by this author , and TOBY C. CHAITOBY C. CHAI More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65726-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Extracellular adenosine triphosphate (ATP) has been shown to mediate inflammation and nociception and, therefore, it may have a role in symptoms associated with interstitial cystitis. We theorized that the bladder uroepithelium releases ATP in response to stretch and, furthermore, this process is augmented in interstitial cystitis. Materials and Methods: We quantitated ATP using the luciferin-luciferase assay. Urinary ATP levels were compared in 35 patients with interstitial cystitis and in 33 normal controls after pH correction. Cultured interstitial cystitis and normal urothelial cells from the bladder biopsies of 5 patients each were stretched with the Flexcell 2000 machine (Flexcell International Corp., McKeesport, Pennsylvania) and supernatant ATP concentrations were measured. Results: Mean urinary ATP plus or minus standard error of mean was significantly higher in patients with interstitial cystitis than in controls (L value 985 ± 161 versus 377 ± 27, p = 0.0007). Supernatant ATP released by stretched interstitial cystitis cells was stretch intensity dependent when comparing 0%, 10% and 20% elongation, and was also significantly higher in stretched interstitial cystitis than in stretched normal cells. Conclusions: Adenosine triphosphate was significantly elevated in the urine of individuals with interstitial cystitis and the stretch activated release of ATP was augmented in interstitial cystitis urothelium. Increased extracellular ATP may have a role in mechanosensory transduction and to our knowledge it represents a novel hypothesis. References 1 : Functional and structural characteristics of the glycosaminoglycans of the bladder luminal surface. J Urol1987; 138: 433. Link, Google Scholar 2 : A deficit of chondroitin sulfate proteoglycans on the bladder uroepithelium in interstitial cystitis. Urology1996; 48: 817. 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Link, Google Scholar From the Division of Urology, Department of Surgery and Division of Infectious Diseases, Department of Internal Medicine, Veterans Administration Maryland Health Care System and Department of Orthopedic Surgery, University of Maryland School of Medicine, Baltimore, Maryland© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byWalsh C, Cheng Y, Mansfield K, Parkin K, Mukerjee C and Moore K (2012) Decreased Intravesical Adenosine Triphosphate in Patients with Refractory Detrusor Overactivity and BacteriuriaJournal of Urology, VOL. 189, NO. 4, (1383-1387), Online publication date: 1-Apr-2013.Nasrin S, Masuda E, Kugaya H, Ito Y and Yamada S (2012) Improvement by Phytotherapeutic Agent of Detrusor Overactivity, Down-Regulation of Pharmacological Receptors and Urinary Cytokines in Rats with Cyclophosphamide Induced CystitisJournal of Urology, VOL. 189, NO. 3, (1123-1129), Online publication date: 1-Mar-2013.Cheng Y, Mansfield K, Allen W, Walsh C, Burcher E and Moore K (2010) Does Adenosine Triphosphate Released Into Voided Urodynamic Fluid Contribute to Urgency Signaling in Women With Bladder Dysfunction?Journal of Urology, VOL. 183, NO. 3, (1082-1086), Online publication date: 1-Mar-2010.Charrua A, Reguenga C, Cordeiro J, Correiade-Sá P, Paule C, Nagy I, Cruz F and Avelino A (2009) Functional Transient Receptor Potential Vanilloid 1 is Expressed in Human Urothelial CellsJournal of Urology, VOL. 182, NO. 6, (2944-2950), Online publication date: 1-Dec-2009.Abouassaly R, Liu G, Yamada Y, Ukimura O and Daneshgari F (2008) Efficacy of a Novel Device for Assessment of Autonomic Sensory Function in the Rat BladderJournal of Urology, VOL. 179, NO. 3, (1167-1172), Online publication date: 1-Mar-2008.Sugaya K, Nishijima S, Tasaki S, Kadekawa K, Miyazato M and Ogawa Y (2007) Mechanisms by Which a Phytotherapeutic Drug Influences Bladder Activity in RatsJournal of Urology, VOL. 179, NO. 2, (770-774), Online publication date: 1-Feb-2008.Kumar V, Chapple C, Surprenant A and Chess-Williams R (2007) Enhanced Adenosine Triphosphate Release From the Urothelium of Patients With Painful Bladder Syndrome: A Possible Pathophysiological ExplanationJournal of Urology, VOL. 178, NO. 4, (1533-1536), Online publication date: 1-Oct-2007.Kanai A, de Groat W, Birder L, Chai T, Hultgren S, Fowler C and Fry C (2018) Symposium Report on Urothelial Dysfunction: Pathophysiology and Novel TherapiesJournal of Urology, VOL. 175, NO. 5, (1624-1629), Online publication date: 1-May-2006.Philip J, Willmott S and Irwin P (2018) Interstitial Cystitis Versus Detrusor Overactivity: A Comparative, Randomized, Controlled Study of Cystometry Using Saline and 0.3 M Potassium ChlorideJournal of Urology, VOL. 175, NO. 2, (566-571), Online publication date: 1-Feb-2006.SUN Y and CHAI T (2018) Up-Regulation of P2X3 Receptor During Stretch of Bladder Urothelial Cells From Patients With Interstitial CystitisJournal of Urology, VOL. 171, NO. 1, (448-452), Online publication date: 1-Jan-2004. Volume 166Issue 5November 2001Page: 1951-1956 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsepitheliumcystitis, interstitialATPurotheliumbladderMetricsAuthor Information YAN SUN More articles by this author SUSAN KEAY More articles by this author PATRICK G. De DEYNE More articles by this author TOBY C. CHAI More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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