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- W2084467300 abstract "Recent studies in adult male rats have shown that gonadal hormones influence performance on certain working memory and other types of cognitive tasks that are sensitive to lesions of the medial and/or orbital prefrontal cortices. This study asked whether gonadal hormone modulation of prefrontal cortical function in males also extends to the perirhinal division of the rat prefrontal cortex. Specifically, sham-operated control, gonadectomized, and gonadectomized rats supplemented with testosterone propionate or estradiol were tested on a spontaneous novel object recognition task, a paradigm where performance has been shown to be impaired by perirhinal cortical lesions. Using analyses of variance, regression analyses and post-hoc testing to evaluate group differences, it was found that during both the sample and test trials of the task all four groups spent similar absolute and proportional amounts of time ambulating, rearing, stationary, and exploring the two objects present. All groups also explored each of the two identical objects present during sample trials equally. However, during the test trials, only the control and gonadectomized rats given testosterone showed the expected increase in exploration of the novel objects presented, whereas the gonadectomized and gonadectomized, estradiol-supplemental groups continued to explore the novel and familiar objects equally. That regression analyses also identified significant correlations between low bulbospongiosus muscle weight and impaired novel vs. familiar object discrimination further indicates that gonadectomy in adult male rats adversely affects spontaneous novel object recognition in an androgen-sensitive, estrogen-insensitive manner." @default.
- W2084467300 created "2016-06-24" @default.
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- W2084467300 date "2008-07-01" @default.
- W2084467300 modified "2023-10-16" @default.
- W2084467300 title "Effects of gonadectomy and hormone replacement on a spontaneous novel object recognition task in adult male rats" @default.
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- W2084467300 doi "https://doi.org/10.1016/j.yhbeh.2008.04.001" @default.
- W2084467300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2517217" @default.
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