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- W2084474057 abstract "Abstract The genomes of evolutionary variants of simian virus 40 (SV40) contain reiterations of DNA sequences derived from the origin of replication of viral DNA. To determine the role of such reiterated DNA segments in the evolution of variants, the relative rates of replication and the encapsidation efficiencies were determined for cloned variants with three, five, six, or nine copies of the SV40 origin sequence. The rate of variant DNA replication relative to that of the helper virus in the variant stock was an exponential function of the number of origin segments per genome. In contrast, encapsidation efficiency was not correlated with the number of origin sequences in the variant genome. We conclude that a major factor in the evolution of SV40 variants is the replicative advantage conferred by the reiteration of the origin of DNA replication." @default.
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- W2084474057 date "1979-01-01" @default.
- W2084474057 modified "2023-09-25" @default.
- W2084474057 title "Evolutionary variants of simian virus 40: Replication and encapsidation of variant DNA" @default.
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- W2084474057 doi "https://doi.org/10.1016/0042-6822(79)90134-x" @default.
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