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- W2084479690 abstract "Synthetic substrates that mimic the properties of extracellular matrix proteins hold significant promise for use in systems designed for tissue engineering applications. In this report, we designed a synthetic polymeric substrate that is intended to mimic chemical, mechanical, and topological characteristics of collagen. We found that elastomeric poly(ester amide) substrates modified with replica-molded nanotopographic features enhanced initial attachment, spreading, and adhesion of primary rat hepatocytes. Further, hepatocytes cultured on nanotopographic substrates also demonstrated reduced albumin secretion and urea synthesis, which is indicative of strongly adherent hepatocytes. These results suggest that these engineered substrates can function as synthetic collagen analogs for in vitro cell culture." @default.
- W2084479690 created "2016-06-24" @default.
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- W2084479690 date "2009-06-01" @default.
- W2084479690 modified "2023-10-10" @default.
- W2084479690 title "Nanofabricated Collagen-Inspired Synthetic Elastomers for Primary Rat Hepatocyte Culture" @default.
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- W2084479690 doi "https://doi.org/10.1089/ten.tea.2008.0134" @default.
- W2084479690 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2789736" @default.
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